Deep brain stimulation reduces symptoms of Parkinson disease
When medications fail to control the symptoms of Parkinson disease, either surgery or a small implanted electrical device can help. With an illustration of how deep brain stimulation works.
E.B. Montgomery, Jr.

A 47-year-old man with leiomyosarcoma and altered mental status
What is the likely cause of this patient's symptoms? A self-quiz on a clinical case.
H.S. Gurm and G.T. Budd

Underused options for preventing and treating influenza
We have the means to prevent most cases of influenza, and to reduce the severity of cases that occur.
S.B. Mossad

Constipation: An approach to diagnosis, treatment, referral
A stepwise, empiric approach suffices in most cases, but specialized testing is available for the minority of patients with severe, refractory constipation.
E.E. Soffer

Complications of sickle cell anemia in adults: Guidelines for effective management
Patients with sickle cell disease are surviving longer, but still face a lifetime of complications and crises.
S.K. Ballas

Diagnosis and management of superior vena cava syndrome
The first manifestations of lung cancer or lymphoma may be due to compression of the superior vena cava.
M. Markman

   INTERPRETING KEY TRIALS ......................................................................................

Zinc lozenges for the common cold
Clinical trials of zinc cold therapy have produced conflicting results.
M.L. Macknin

The Breast Cancer Prevention Trial (P-1 study): The role of tamoxifenin preventing breast cancer
Tamoxifen can reduce the incidence of breast cancer by nearly half in women at high risk, but at the price of increased endometrial cancer and thromboembolism. An illustration shows the differing effects of tamoxifen in different organs.
B.A. Overmoyer