ABSTRACT
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut “winner,” it does provide guidance on how to start therapy and how to proceed if initial treatment fails.
Footnotes
↵* The authors’ disclosures of potential conflicts of interest are listed at the end of this paper.
- Copyright © 2008 The Cleveland Clinic Foundation. All Rights Reserved.
- Bradley N. Gaynes, MD, MPH⇑*,
- A. John Rush, MD*,
- Madhukar H. Trivedi, MD*,
- Stephen R. Wisniewski, PhD*,
- Donald Spencer, MD, MBA* and
- Maurizio Fava, MD*
- Associate Professor of Psychiatry, University of North Carolina School of Medicine; Investigator, Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study
- University of Texas Southwestern Medical Center at Dallas; Professor of Clinical Sciences and Psychiatry; Principal Investigator, STAR*D study
- University of Texas Southwestern Medical Center at Dallas; Professor of Psychiatry; National Coordinating Center, STAR*D study
- University of Pittsburgh School of Medicine; Associate Professor of Epidemiology; Data Coordinating Center, STAR*D study
- University of North Carolina School of Medicine; Professor of Family Medicine; Investigator, STAR*D study
- Massachusetts General Hospital, Boston; Professor of Psychiatry; Investigator, STAR*D study
- ADDRESS:
Bradley N. Gaynes, MD, MPH, Department of Psychiatry, University of North Carolina at Chapel Hill, First Floor, Neurosciences Hospital, Room 10306, CB#7160, Chapel Hill, NC 27599; e-mail bgaynes{at}med.unc.edu.
ABSTRACT
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut “winner,” it does provide guidance on how to start therapy and how to proceed if initial treatment fails.
Footnotes
↵* The authors’ disclosures of potential conflicts of interest are listed at the end of this paper.
- Copyright © 2008 The Cleveland Clinic Foundation. All Rights Reserved.