Liver transplantation and neurological side effects

Metab Brain Dis. 2009 Mar;24(1):183-7. doi: 10.1007/s11011-008-9119-0. Epub 2009 Jan 13.

Abstract

Advances in liver transplantation (LT), particularly in immunosuppression and intensive care treatment have had increased the number of long-term survivors following liver transplantation. In order of more long-term survivors, reports about neurological complication following liver transplantation are increasing. Neurological complications are not uncommon in liver transplant recipients, which contribute to a longer ICU- and in-hospital stay. Every effort should be focused on early detection to prevent the patient from this life-threatening event, which is often associated with poor life quality.

Publication types

  • Review

MeSH terms

  • Brain / drug effects
  • Brain / metabolism
  • Brain / physiopathology
  • Calcineurin / metabolism
  • Calcineurin Inhibitors*
  • Cyclosporine / adverse effects*
  • Early Diagnosis
  • Hepatic Encephalopathy / metabolism
  • Hepatic Encephalopathy / physiopathology
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Liver Transplantation / adverse effects*
  • Neurotoxicity Syndromes / etiology*
  • Neurotoxicity Syndromes / physiopathology*
  • Postoperative Complications / chemically induced
  • Postoperative Complications / etiology
  • Postoperative Complications / physiopathology
  • Tacrolimus / adverse effects*

Substances

  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Cyclosporine
  • Calcineurin
  • Tacrolimus