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INTERPRETING KEY TRIALS

Purpose: This series is designed to update physicians on important clinical trials that are changing the practice of medicine, summarizing the study’s rationale, methods, and results. But more importantly, articles for this series should put the trial into perspective, clarifying the key clinical take-home points, as well as outlining ambiguities in results, unanswered questions and controversies.

Style: The style of the article should be similar to that of a CME presentation, using a minimum of jargon and highlighting key points and new developments that the internist can quickly incorporate into his or her practice.

Format: Articles should be about 2,500 words long (not counting references, tables, or figures) with about 30 key references. The abstract should be about 100 words long.

Content: Most articles for this series are organized in the same way; they begin with a discussion of the rationale for the study, followed by a summary of the study design, and then an overview of the important results. Perhaps most importantly for CCJM readers, the article should then discuss the results in a nuanced way, emphasizing the important findings that may change clinical practice, but also the unanswered questions and controversies, and what new questions the study raises.

Example: Coronary atherosclerosis can regress with very intensive statin therapy