The uric acid hypothesis: Out with the old, in with the...old
The death knell for the idea that serum urate mediates cardiovascular disease tolled about 25 years ago. But now the concept is being revived.
B.F. MANDELL

Hope drives antiaging hype
The road to perpetual youth is paved with (fool's) gold.
T.T. PERLS

Antioxidants and hormones as antiaging therapies:
High hopes, disappointing results
We review the evidence of efficacy (or lack thereof) for two types of agents touted as antiaging therapies.
N.S. KAMEL, J. GAMMACK, O. CEPEDA, and J.H. FLAHERTY

Role of uric acid in hypertension, renal disease, and metabolic syndrome
Clinical gout is just the tip of the iceberg: We believe that elevated uric acid is actually one of the most important risk factors for cardiovascular disease and that it plays a role in renal disease and metabolic syndrome as well.
M. HEINIG and R.J. JOHNSON

Cystic fibrosis in adults: An overview for the internist
Cystic fibrosis is no longer a purely pediatric disease; the median life expectancy is now more than 40 years.
A.J. GERSHMAN, A.C. MEHTA, M. INFELD, and M.M. BUDEV

PET and PET/CT imaging: What clinicians need to know
How positron emission tomography (PET) and PET/computed tomography (PET/CT) work and are showing promise in clinical oncology, cardiology, and neurology.
B. BYBEL, R.C. BRUNKEN, S.N. SHAH, G. WU, E. TURBINER, and D.R. NEUMANN

A woman with aplastic anemia and a rash
A patient who is receiving multiple drugs, including several antibiotics, develops a rash on her chest, abdomen, and extremities. What is the most likely diagnosis?
I. TAMASKAR, E. SEGOTA, M. KALAYCIO, and J. MACIEJEWSKI

Hypotension in the intensive care unit
Our patient's vital signs: temperature 98.4ºF, pulse 96 and regular, respirations 23, blood pressure 76/44 mm Hg, central venous pressure 21 mm Hg. What is the likely cause of his hypotension?
A. AL-HAZZOURI and P. MAZZONE

Treating depression in pregnancy: Practical suggestions
Treating depression in a pregnant woman is a balance between relieving the mother's depression and minimizing the baby's exposure to potentially harmful drugs.
L. GONSALVES and I. SCHUERMEYER

Cardiovascular interventions in older elderly are not useful

Index to Volume 73