Cleveland Clinic Journal of Medicine

Unresolved Problems in Heart Failure:
Edema, Hyponatremia, and Renal Insufficiency

Supplement 2 to Volume 73, June 2006

Supplement Editor:

GARY FRANCIS, MD
Head, Clinical Cardiology Section
Department of Cardiovascular Medicine
Professor of Medicine, Cleveland Clinic Lerner College of Medicine
of Case Western Reserve University
Cleveland Clinic

This supplement is based on the complete proceedings of a satellite symposium held in March 2006 prior to the American College of Cardiology (ACC) Annual Scientific Session. The symposium was not part of the official ACC Annual Scientific Session as planned by the Annual Scientific Session Program Committee. Articles in this supplement were developed by the Cleveland Clinic Journal of Medicine staff based on transcripts of faculty presentations at the symposium, and then each article was revised and approved by the respective author/presenter.

Supplement
June
2006

Supplement 2
to Volume 73

This supplement is supported by an educational grant from Otsuka America Pharmaceutical, Inc.

This supplement was developed in print form
as a certified CME activity. To complete the activity for free CME credit, request a free print copy of the supplement by e-mailing dunaskk@ccf.org.

Guidelines for grant-supported supplements to the Cleveland Clinic Journal of Medicine

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CONTENTS

Author and Editor Disclosures
Sodium and water retention in heart failure and diuretic therapy: Basic mechanisms Domenic A. Sica, MD Acute decompensated heart failure: The cardiorenal syndrome Gary Francis, MD New approaches to detect and manage edema and renal insufficiency in heart failure W.H. Wilson Tang, MD Vasopressin receptor antagonists: Mechanisms of action and potential effects in heart failure Steven R. Goldsmith, MD The clinical effects of vasopressin receptor antagonists in heart failure Mihai Gheorghiade, MD Panel discussion
Copyright © 2006 The Cleveland Clinic Foundation. The statements and opinions expressed in this supplement to the Cleveland Clinic Journal of Medicine are those of the authors and not necessarily of Cleveland Clinic Foundation, its Board of Trustees, or Otsuka America Pharmaceutical, Inc. They do not necessarily represent formal practice guidelines in effect at Cleveland Clinic. *The Cleveland Clinic Journal of Medicine* (ISSN 0891-1150) is published 12 times yearly by The Cleveland Clinic Foundation.** Subscription rates: U.S. and possessions: personal $103; institutional $129; single copy/back issue $18. Foreign: $129; single copy/back issue $18. Institutional (multiple-reader rate) applies to libraries, schools, hospitals, and federal, commercial, and private institutions and organizations. Individual subscriptions must be in the names of, billed to, and paid by individuals. Postmaster address changes: Cleveland Clinic Journal of Medicine, NA32, 9500 Euclid Avenue, Cleveland, OH 44195. Subscription orders, editorial, reprint, and production offices (same address): (216) 444-2661 (phone); (216) 444-9385 (fax); ccjm@ccf.org (e-mail); www.ccjm.org (Web). Printed in USA.