Old drug, new use, continued vigilance
Colchicine, an old and familiar drug for gout, has found another use in preventing and treating pericarditis. But familiarity should not dampen vigilance.
B.F. MANDELL

Parkinson disease:
Managing a complex, progressive disease at all stages
Parkinson disease is complex to manage. Its presentation can vary, as can its response to treatment. Physicians tend to focus on its motor symptoms, but many patients find nonmotor symptoms equally troublesome.
M.L. GIROUX

In vitro fertilization update
The science of in vitro fertilization has improved considerably in the last 25 years. We provide an overview of the current and experimental techniques of assisted reproductive technology.
J.M. GOLDBERG, T. FALCONE, and M. ATTARAN

Anabolic steroid abuse: Psychiatric and physical costs
Anabolic-androgenic steroid abuse is no longer confined to professional athletes. Physicians should be aware of its signs and symptoms so that they can address its adverse effects and treat it.
F. TALIH, O. FATTAL, and D. MALONE JR

Viral infections and the kidney: HIV, hepatitis B, and hepatitis C
Ten years ago, viral glomerulonephritis was usually regarded as untreatable. Now treatments are available for the top three causes: HIV, hepatitis B, and hepatitis C.
G. APPEL

Intravenous iodinated contrast agents:
Risks and problematic situations
Many diagnostic imaging studies use intravenous contrast media. Although these agents are generally safe, they do pose some risk of adverse reactions.
K.L. BUI, J.D. HORNER, B.R. HERTS, and D.M. EINSTEIN

Newer hormonal therapies: Lower doses; oral, transdermal, and vaginal formulations
We review some of the hormonal regimens that have been approved in the past 5 years.
M.S. SIVANANDY, N. MASIMASI, and H.L. THACKER

Neurologic effects of hyponatremia and its treatment
Twenty-one days after surviving a hemorrhagic stroke, the patient develops new neurologic symptoms. A computed tomographic scan shows new cerebral edema. Her serum sodium concentration is 121 mmol/L.
P. WIDDESS-WALSH, V. SABHARWAL, S. DEMIRJIAN,
and M. DeGEORGIA

Should all patients with acute pericarditis be treated with colchicine?
Colchicine should be considered a first-line treatment for acute pericarditis and for preventing recurrent episodes.
H. SALTZMAN and H.H. WEITZ

Antioxidants may increase mortality

Diet, exercise, drugs may prevent diabetes in high-risk patients

Optimal dosing for thromboprophylaxis in medical inpatients

Glitazones may be beneficial after percutaneous coronary intervention