Oil it where it squeaks: Evidence, experience, and osteoarthritis therapy
Since many patients with osteoarthritis do experience relief with intra-articular therapy, it may indeed pay to "oil it where it squeaks." I just wonder how much it matters what oil we use.
B.F. MANDELL

When can patients with acute deep vein thrombosis be allowed to get up and walk?
They should ambulate as tolerated. Bed rest is not evidence-based and may be harmful.
L.S. FELDMAN and D.J. BROTMAN

Intra-articular injections for osteoarthritis of the knee
If usual medical measures fail to control the pain of osteoarthritis of the knee, intra-articular injections of a corticosteroid,a hyaluronan, or both may help.
D.H. NEUSTADT

Recurrent pregnancy loss: Evaluation and discussion of the causes and their management
Women who miscarry two or more consecutive pregnancies deserve an evaluation to look for the cause, which sometimes can be treated.
R. KIWI

Headaches in older patients: Special problems and concerns
Any patient older than 50 years who develops headaches for the first time or who has a change in a chronic headache pattern should be investigated for an underlying cause or exacerbating condition.
R.S. KUNKEL

Using the new HPV vaccines in clinical practice
The new vaccines against human papillomavirus (HPV) could prevent up to 70% of cases of cervical cancer. But Pap testing will still be necessary.
L.E. WIDDICE and J.A. KAHN

Interpreting the ASTEROID trial. Coronary atherosclerosis can regress with very intensive statin therapy
The optimal strategy for lipid-lowering in patients with coronary artery disease may be to aim for the lowest low-density lipoprotein cholesterol level that can be attained without adverse effects.
I. SIPAHI, S.J. NICHOLLS, E.M. TUZCU, and S.E. NISSEN

Beyond cardiovascular risk: The impact of obesity on cancer death
We summarize the evidence supporting a link between obesity and cancer, discuss possible explanations, and recommend ways to enhance cancer prevention.
B.C. BORDEAUX, S. BOLEN, and D.J. BROTMAN

Lowering homocysteine with B vitamins does not improve cognition

Red hot chili pepper does not worsen hemorrhoid symptoms

Raloxifene decreases breast cancer risk, but has no effect on cardiovascular risk

Cyclophosphamide reduces dyspnea in scleroderma lung disease

Letter to the Editor
Are statins 'smart bombs'? (August 2006)