Who is conducting the deadly quartet?
The metabolic syndrome warrants aggressive intervention and prevention, even if we cannot explain it yet.
B.F. Mandell

Emphysema in nonsmokers: Alpha 1-antitrypsin deficiency and other causes
The 10% of patients with emphysema who never smoked deserve a workup for its less common causes, including genetic risk modifiers and occupational exposures.
P. LEE, T.R. GILDEA, and J.K. STOLLER

Update on the diagnosis and treatment of human papillomavirus infection
Genotyping can distinguish viral subtypes that pose a high risk for cancer, but current therapies do not reliably eradicate the virus, and warts and neoplasia often recur after treatment.
K.M. ZANOTTI and J. BELINSON

The HIP trial
Risedronate prevents hip fractures, but who should get therapy?
Patients should be selected for bisphosphonate therapy on the basis of low bone density, not age.
C.L. DEAL

Gallbladder disease: An update on diagnosis and treatment
Current diagnostic techniques and treatments offer results equal to or better than those of earlier methods, are less invasive, and allow patients to recover faster.
D.P. VOGT

A truly deadly quartet: Obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia
The best available treatment is to control one’s weight, exercise regularly, stop smoking, and eat a healthy diet.
V. NAMBI, B.J. HOOGWERF, and D.L. SPRECHER

The metabolic syndrome: A tug-of-war with no winner
Even before beta cells fail, the deadly quartet is quietly rehearsing.
D.J. BROTMAN and J.P. GIROD

HIV update 2002: Delaying treatment to curb rising resistance
“Treat early, treat hard” is changing to “treat a little later, treat hard.”
W. ARMSTRONG, L. CALABRESE, and A. TAEGE

  Which children and adults should receive the chickenpox vaccine?
It should be given to all seronegative children and adults in whom it is not otherwise contraindicated.
C. SABELLA

Classifieds
Index to Volume 69
CME Self-test