A pox upon human folly
In mass smallpox vaccination, the choices aren’t pretty or easy
J.D. CLOUGH

Pre-event smallpox vaccination: Unresolved issues
We are on the verge of the first phase of nationwide smallpox vaccination, but many questions remain unanswered.
S.M. GORDON

Vertebral compression fractures: What time destroys, methylmethacrylate may mend
The sequelae of osteoporosis present numerous clinical challenges; several new surgical options show promise.
C.M. BONO

  What are the key issues women face when ending hormone replacement therapy?
A logical approach is to review why the patient is on HRT and to consider alternatives.
W.H. UTIAN

  What is the appropriate treatment for Dupuytren contracture?
The diseased tissue is either watched with benign neglect or surgically excised.
T.R. HUNT III

  How do you manage a healthy, asymptomatic, 24-year-old patient with a positive RPR on a premarital blood test?
A positive rapid plasma reagin must be confirmed or refuted, but if the history, physical, and laboratory studies are negative, there is a great chance it was falsely positive.
S.B. MOSSAD

Worsening shortness of breath
ECGs from a 58-year-old man with type 2 diabetes who presents to the emergency room with dyspnea.
M. SHAAROUI and C.M. RIMMERMAN

Fungal nail infection: Assessing the new treatment options
Newer antifungal agents are more effective and better tolerated than older agents.
G. BOTEK

Challenges and choices in drug therapy for chronic pain
Chronic pain is different from acute pain, and its treatment is more challenging.
S.M. FISHMAN and D. TEICHERA

Improving care of chronic heart failure: Advances from drugs to devices
The right combination of drugs and surgical treatment can improve systolic function and prevent, attenuate, or reverse heart failure.
R.C. STARLING

Vertebral compression fractures: Manage aggressively to prevent sequelae
Advances in preventing and managing acute vertebral compression fractures can reduce their devastating impact, even in the face of an aging population.
D.J. MAZANEC, V.K. PODICHETTY, A. MOMPOINT, and A. POTNIS

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