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J.D. CLOUGH and P. STUDER

A traveler with nonhealing skin nodules
Questions and answers on the visible signs of diseases.
J.K. HIX and M. RAHMAN

Malignant melanoma: Treatments emerging, but early detection still key
Interferon alfa-2b can increase disease-free survival in malignant melanoma, but we can have far more impact by detecting this disease earlier and by teaching patients how to recognize and possibly avoid it.
P. MASCI and E.C. BORDEN

Why shouldn’t we use warfarin alone to treat acute venous thrombosis?
Heparins produce desired levels of anticoagulation within hours, whereas warfarin takes at least 4 days.
T. CHOUEIRI and S.R. DEITCHER

A 76-year-old man with septic arthritis
What is the cause of this patient’s symptoms? A self-test.
P.N. THOTA, M.R. SANAKA, and D.L. CONWELL

GUSTO V: Combination drug treatment of acute myocardial infarction
The combination of abciximab in full doses and reteplase in half doses was not superior to full-dose reteplase alone, but it was “not inferior” either.
A.T. ASKARI and A.M. LINCOFF

GUSTO V: Should it affect clinical practice?
The results of GUSTO V were equivocal and should not lead physicians to change how they treat myocardial infarction.
J.L. ORFORD and P.B. BERGER

Aromatase inhibitors in breast cancer: Current and evolving roles
Aromatase inhibitors are finding new uses. Already established for treating metastatic breast cancer in postmenopausal women, they are gaining acceptance as adjuvant treatment as well.
J. HILL and H. MOORE

Acute renal failure in hospitalized patients
Acute renal failure demands a logical approach to its prevention and early diagnosis.
J.V. NALLY, JR.

Letters to the Editor
Coxibs supplement: Has CCJM sold out?

Hereditary hemochromatosis (Cleve Clin J Med 2002; 69:224–237).