AIDS update 1999: Viral reservoirs and immune-based therapies
Recent discoveries have dampened optimism for a cure, though they suggest new avenues of research.
C.M. Isada and L.H. Calabrese

Resuscitating the exercise stress test
Old does not necessarily mean obsolete. The exercise stress test can still provide useful information, provided we ask the right questions.
M.S. Lauer

A 42-year-old man with microcytic anemia and hypocalcemia
What is the likely cause of this patient’s symptoms? A self-test on a clinical case.
C.A. Matteoni and J.J. Vargo II

Brief answers to specific clinical questions

  What is the optimal strategy for colon cancer surveillance in patients with ulcerative colitis?
In view of the increased risk, these patients need to undergo colonoscopy on a regular basis—and fairly frequently.
W.M. Bauer and B.A. Lashner

COX 2-selective NSAIDS: Biology, promises, and concerns
A new family of nonsteroidal anti-inflammatory drugs promises to be substantially safer than current agents, but should not be assumed to be totally without adverse effects.
B.F. Mandell

New insulin replacement technologies: Overcoming barriers to tight glycemic control
Several new pharmacologic and technologic innovations should make life easier for diabetic patients who require insulin. With an illustration depicting new options that are either available or under development.
C.A. Leslie

Colorectal cancer screening: Making sense of the different guidelines
Colon cancer screening is dismally under-used. A review of the guidelines from three different groups, with recommendations in areas of controversy.
C.A. Burke and R. Van Stolk

Gastrointestinal and renal involvement in vasculitis: Management strategies in Henoch-Schönlein purpura
Available evidence favors a short course of oral corticosteroids for gastrointestinal involvement and aggressive immunotherapy for progressive HSP nephritis, but the data are sparse.
I.S. Szer