Secondary headache disorders such as neoplasm or infection are more often suspected than detected, but neuroimaging is warranted when red-flag features are present.

Activation of the immune system can be associated with many off-target manifestations.

There is much confusion about who is using kratom, what the drug does, and what we physicians should do about it.

The authors offer practical guidance on identifying pulmonary nodules that require surveillance, determining appropriate follow-up intervals, and deciding when specialist evaluation and intervention are needed.

Amid the opioid crisis, kratom use has grown for self-management of pain, mood symptoms, and opioid withdrawal.