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Cleveland Clinic Journal of Medicine

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Current Issue

01 May 2026 (Vol. 93 Issue 5) Table of Contents
Cleveland Clinic Journal of Medicine: 93 (5)

Issue highlights

  • Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
  • Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
  • Fighting ageism: Preserving patient agency in critical care

Summaries from AACE 2026

Summaries from Kidney Week 2025

Featured Articles

  • Varicella-zoster virus transmission from herpes zoster exposure
    May 01, 2026
  • Unexplained liver injury: Searching for the cause
    May 01, 2026
  • ‘Even when the wound is healed, the scar remains’
    May 01, 2026
  • Clinical application of the complement system: A historical perspective
    April 01, 2026
  • Interpreting the DIGIT-HF trial: Time for a new look at digitalis?
    April 01, 2026
  • A 20-year-old woman with a 9-year history of shortness of breath
    April 01, 2026
  • ‘Boxing glove’ hands in a patient initially diagnosed with RS3PE syndrome
    March 02, 2026
  • Getting stuck on a name: An example of an eponymous syndrome
    March 02, 2026
  • Right ventricular failure in a young man
    February 02, 2026
  • Suzetrigine: A novel nonopioid systemic analgesic
    February 02, 2026
  • Should potassium-competitive acid blockers replace proton pump inhibitors as first-line therapy for...
    February 02, 2026

Latest Articles

  • You have access
    Fighting ageism: Preserving patient agency in critical care
    Astefanos Al-Dalakta, MD, Ruth Diana Lee, MD, Chadi Tabaja, MD, Issam Motairek, MD and Eduardo Mireles-Cabodevila, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 263-265; DOI: https://doi.org/10.3949/ccjm.93a.25105

    To avoid falling into ageism bias, we must maintain a framework grounded in respect for the patient, one that deliberately centers on the patient’s voice.

  • You have access
    FINEARTS-HF: Improving outcomes in heart failure with preserved or mildly reduced ejection fraction
    Salman Salahuddin, MD, DM, MRCP(UK)
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 273-277; DOI: https://doi.org/10.3949/ccjm.93a.25081

    FINEARTS-HF established finerenone as an effective medical therapy to reduce hospitalizations for heart failure in patients with HFpEF or HFmrEF.

  • You have access
    Iris roseola: A diagnostic clue in neurosyphilis
    Victor Alegre-Ituarte, MD, PhD and Elena Franz-Lacomba, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 259-260; DOI: https://doi.org/10.3949/ccjm.93a.25047

    The patient had a 3-week history of decreased vision in the left eye, with a best-corrected visual acuity of 20/100.

  • You have access
    Varicella-zoster virus transmission from herpes zoster exposure
    Ayano Takeiri, MD, Kentaro Ishikura, MD and Yoshitaka Tomoda, MD, PhD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 261-262; DOI: https://doi.org/10.3949/ccjm.93a.25068

    Two weeks before the patient developed fever and a rash, his mother had developed herpes zoster on her torso.

  • You have access
    Unexplained liver injury: Searching for the cause
    Mohamed Eldib, MD, William D. Carey, MD and Blazenka Skugor, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272; DOI: https://doi.org/10.3949/ccjm.93a.25099

    The patient presented with persistent low back pain, nausea, poor appetite, and an unintentional weight loss of more than 30 lb over the previous 6 weeks.

  • You have access
    Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline
    Paru S. David, MD, MSCP, Hannah Nordhues, MD, MSCP and Suneela Vegunta, MD, MSCP
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 297-303; DOI: https://doi.org/10.3949/ccjm.93a.25049

    Sex-specific factors like adverse pregnancy outcomes and premature and early menopause play a critical and often underrecognized role in shaping lifetime stroke risk in women.

  • You have access
    ‘Even when the wound is healed, the scar remains’
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 255-256; DOI: https://doi.org/10.3949/ccjm.93b.05026

    Persistent or repetitive inflammatory or ischemic insults to internal organs may lead to progressive scarring that culminates in organ failure.

  • Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
    You have access
    Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
    Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 289-295; DOI: https://doi.org/10.3949/ccjm.93a.26003

    Clonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.

  • You have access
    Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
    CME article
    Leandro Sierra, MD, Lily Liu, MD, Akash Khurana, MD, Roma Patel, MD, Arjun Chatterjee, MD, Stephen Firkins, MD and Roberto Simons-Linares, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286; DOI: https://doi.org/10.3949/ccjm.93a.25082

    Weight loss of at least 10% is associated with fibrosis regression in most patients, but losing this amount of weight and keeping it off is challenging, making pharmacologic and procedural interventions essential tools in clinical practice.

  • You have access
    ‘All that wheezes is not asthma’—a reminder that the physical examination
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195; DOI: https://doi.org/10.3949/ccjm.93b.04026

    In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

View more latest articles
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Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline
FINEARTS-HF: Improving outcomes in heart failure with preserved or mildly reduced ejection fraction
Iris roseola: A diagnostic clue in neurosyphilis
‘All that wheezes is not asthma’—a reminder that the physical examination
Treating perinatal mood and anxiety disorders: A call to action
Palatal mass with an overlying white lesion
Ogilvie syndrome (colonic pseudo-obstruction)
Alpha-1 antitrypsin deficiency: A persistently underrecognized condition
Westermark sign (focal oligemia) in pulmonary embolism
A new direction in pain management?
Profound xanthomas in a young man
Xanthomas: A clue to undiagnosed lipid disorders

Cleveland Clinic Journal of Medicine, published by Cleveland Clinic, provides busy clinicians with practical information to promote better patient care.

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