The author explores how IgE was discovered, the challenges researchers faced when isolating the antibody, and the connection among IgE, mast cells, and histamine.

After more than 1 month of acetaminophen, the patient continued to have fever and elevated inflammatory markers.

Bedside screening tools can be used to distinguish delirium from other causes of altered mental status, enabling timely care and reducing costs.

Telogen effluvium, or hair shedding, results from a temporary disruption of the normal hair growth cycle and typically is reversible.

Results of the EVERDAC trial challenge the strategy of reflexively placing an arterial line when a patient is admitted to the intensive care unit.

The patient presented with dizziness that started earlier that morning when she rose from bed, persisted after she returned to bed, and worsened with head movement.

Indiscriminate testing can lead to misinterpretation of results, unnecessary escalation of therapy, and increased cost without clinical benefit.

Some diagnostic tools that were supposed to render the bedside examination less relevant have themselves failed the test of necessity; meanwhile, the bedside skills they supposedly would displace have also atrophied.

The new guideline, which updates the 2016 guideline, clarifies clinical terminology, applies trial evidence to pharmacotherapy and revascularization recommendations, and addresses equity and access to care.