ABSTRACT
Recent decades have seen great advances in the understanding of chronic kidney disease, spurred by standardizing disease definitions and large-scale patient surveillance. African Americans are disproportionately affected by the disease, and recently discovered genetic variants in APOL1 that protect against sleeping sickness in Africa provide an important explanation for the increased burden. Studies are now under way to determine if genetic testing of African American transplant donors and recipients is advisable.
- Copyright © 2017 The Cleveland Clinic Foundation. All Rights Reserved.
- Joseph V. Nally Jr, MD⇑
- Former Director, Center for Chronic Kidney Disease
- Clinical Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
- ADDRESS:
Joseph V. Nally, Jr., MD, Glickman Urological and Kidney Institute, Q7, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; nallyj{at}ccf.org
ABSTRACT
Recent decades have seen great advances in the understanding of chronic kidney disease, spurred by standardizing disease definitions and large-scale patient surveillance. African Americans are disproportionately affected by the disease, and recently discovered genetic variants in APOL1 that protect against sleeping sickness in Africa provide an important explanation for the increased burden. Studies are now under way to determine if genetic testing of African American transplant donors and recipients is advisable.
- Copyright © 2017 The Cleveland Clinic Foundation. All Rights Reserved.