A new paradigm for adult ADHD ============================= * Vania Modesto-Lowe * Samantha Frigon **To the Editor:** Adults with attention deficit hyperactivity disorder (ADHD) experience sustained attention deficits manifested with accompanying difficulties completing tasks.1,2 While ADHD symptoms cause significant impairment, many affected adults remain untreated.1 Efforts to improve recognition and management include the development of ADHD symptom scales for screening and treatment monitoring of these patients.1 In the recent commentary by Drs. Manos and Short,2 task incompletion is regarded as the primary dysfunction in adults. Accordingly, the authors suggest that task completion should be used as a measure to track pharmacologic therapy response in these patients. This is conceptually plausible since several adult ADHD diagnostic criteria relate to task completion, eg, “reluctance to start or to persist with tasks requiring sustained mental effort.”3 Clinical assessments to help evaluate task completion difficulties include the use of continuous performance tests (CPTs), which can measure attention and require the individual to respond to targets (a measure of attention) and to inhibit response to non-targets (a measure of impulsivity).4 Marchetta et al5 found a deterioration of time-on-task in adults with ADHD relative to controls. Babajanyan et al3 noted 3 patterns that decreased task completion. These patterns included complete lapses in attention, partial attention to a task, and engaging in multiple tasks. However, disagreement exists on whether the ability to stay on task as measured by CPTs can accurately reflect the severity of ADHD. Baggio et al6 examined CPTs as a marker of adult ADHD presentation and severity and reported small correlations between CPT variables and ADHD symptoms determined by a clinical interview: 51.7% of the sample were classified as likely to have ADHD by CPTs. The classification error was 80.3% for the inattentive subtype and 22.5% for the hyperactive subtype.6 While the utility of CPTs to assess or monitor ADHD in adults appears limited, task completion itself may be a more suitable clinical measure. However, this remains to be empirically demonstrated in reliability and validity studies before it can be widely implemented in clinical settings. * Copyright © 2023 The Cleveland Clinic Foundation. All Rights Reserved. ## REFERENCES 1. Modesto-Lowe V, Boninsegna K, Fredeen M. Improving attention-deficit/hyperactivity disorder recognition in family practice. Fam Pract 2023:cmad026. doi:10.1093/fampra/cmad026 [CrossRef](http://www.ccjm.org/lookup/external-ref?access_num=10.1093/fampra/cmad026&link_type=DOI) 2. Manos MJ, Short EJ. A new paradigm for adult ADHD: a focused strategy to monitor treatment. Cleve Clin J Med 2023; 90(7):413–421. doi:10.3949/ccjm.90a.22080 [FREE Full Text](http://www.ccjm.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiRlVMTCI7czoxMToiam91cm5hbENvZGUiO3M6NToiY2Nqb20iO3M6NToicmVzaWQiO3M6ODoiOTAvNy80MTMiO3M6NDoiYXRvbSI7czoyMzoiL2Njam9tLzkwLzEwLzU5Mi4xLmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==) 3. Babajanyan D, Freame L, Steele R, Poulton A. Understanding attentional functioning in adult attention deficit hyperactivity disorder: could this improve diagnostic specificity? Int J Environ Res Public Health 2023; 20(6):5077. doi:10.3390/ijerph20065077 [CrossRef](http://www.ccjm.org/lookup/external-ref?access_num=10.3390/ijerph20065077&link_type=DOI) 4. Kenton JA, Young JW. Preclinical evaluation of attention and impulsivity relevant to determining ADHD mechanisms and treatments. Curr Top Behav Neurosci 2022; 57:291–320. doi:10.1007/7854\_2022\_340 [CrossRef](http://www.ccjm.org/lookup/external-ref?access\_num=10.1007/7854_2022_340&link_type=DOI) 5. Marchetta ND, Hurks PP, De Sonneville LM, Krabbendam L, Jolles J. Sustained and focused attention deficits in adult ADHD. J Atten Disord 2008; 11(6):664–676. doi:10.1177/1087054707305108 [CrossRef](http://www.ccjm.org/lookup/external-ref?access_num=10.1177/1087054707305108&link_type=DOI) [PubMed](http://www.ccjm.org/lookup/external-ref?access_num=17712171&link_type=MED&atom=%2Fccjom%2F90%2F10%2F592.1.atom) 6. Baggio S, Hasler R, Giacomini V, El-Masri H, Weibel S, Perroud N, Deiber MP. Does the continuous performance test predict ADHD symptoms severity and ADHD presentation in adults? J Atten Disord 2020; 24(6):840–848. doi:10.1177/1087054718822060 [CrossRef](http://www.ccjm.org/lookup/external-ref?access_num=10.1177/1087054718822060&link_type=DOI)