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Cleveland Clinic Journal of Medicine

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Table of Contents

December 01, 2025; Volume 92,Issue 12

From the Editor

  • You have access
    Diabetes: Putting off until tomorrow what could happen today can be good
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 715-717; DOI: https://doi.org/10.3949/ccjm.92b.12025

    Prevention of beta-cell loss and preservation of endogenous insulin production have been attractive treatment prerogatives in type 1 diabetes.

The Clinical Picture

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    Trident sign in osmotic demyelination syndrome
    Erin Equinozzi, MSc, Clement D. Lee, MD, MSc and Pamela Schaefer, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 732-733; DOI: https://doi.org/10.3949/ccjm.92a.24080

    Brain magnetic resonance imaging showed a confluent trident-shaped lesion in the central pons 1 week after correction of the patient’s chronic hyponatremia.

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    Acute transient phlebitis after a morphine infusion
    Alexandros Makris, MD, PhD, MSc, Alexandros Nikas, MD and Anastasios Bontozis, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 734-735; DOI: https://doi.org/10.3949/ccjm.92a.25007

    Prominent ascending erythema outlining the infused vein and its proximal branches developed quickly after infusion.

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    Skin manifestations of mpox
    James Kim, MD, Matt Biondi, MD and Helen Bartels, MB, BChir
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 736-737; DOI: https://doi.org/10.3949/ccjm.92a.25022

    The patient presented with a tender, ulcerated perianal lesion and scattered papules on the trunk and extremities.

1-Minute Consult

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    How should I incorporate emergency contraception counseling into my practice?
    Alexa R. Wilden, MD and Heather M. Wainstein, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 738-741; DOI: https://doi.org/10.3949/ccjm.92a.25029

    Emergency contraception counseling should be provided routinely to women at risk of unintended pregnancy as part of counseling on reproductive goals.

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    Should I consider low-dose rivaroxaban (2.5 mg) for my patient with peripheral artery disease?
    Pranay Marlecha, MD, Deborah Hornacek, MD and Pulkit Chaudhury, MD, MS
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 742-744; DOI: https://doi.org/10.3949/ccjm.92a.25065

    For patients with high ischemic risk, rivaroxaban 2.5 mg twice daily with aspirin 81 or 100 mg daily is a proven strategy to reduce major cardiovascular and limb events.

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    How can I select the right thyroid hormone formulation for my patient with hypothyroidism?
    Lea El Hage, MD and Vinni Makin, MBBS, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 745-747; DOI: https://doi.org/10.3949/ccjm.92a.25042

    Knowing the features of the available thyroid hormone formulations can provide a starting point for individualizing therapy for patients who have concerns about product formulations or remain symptomatic despite a normal thyroid-stimulating hormone level.

Symptoms to Diagnosis

  • Finding the cause of severe hypokalemia: A 4-step approach
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    Finding the cause of severe hypokalemia: A 4-step approach
    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 748-756; DOI: https://doi.org/10.3949/ccjm.92a.25055

    This case illustrates the approach to a group of conditions associated with hypokalemia that usually pose a diagnostic challenge.

Review

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    Latent autoimmune diabetes in adults: Not type 1, not type 2, a little of both
    CME article
    Michelle D. Lundholm, MD and Keren Zhou, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 757-763; DOI: https://doi.org/10.3949/ccjm.92a.25069

    Latent autoimmune diabetes in adults shares features of type 1 and type 2 diabetes, often leading to misdiagnosis and a delay in starting needed insulin therapy.

Editorial

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    LADA: A case for starting insulin therapy at diagnosis
    Byron J. Hoogwerf, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 764-766; DOI: https://doi.org/10.3949/ccjm.92a.25084

    The author discusses factors that support starting insulin therapy at diagnosis in all patients with latent autoimmune diabetes in adults.

Letter to the Editor

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    Barriers to cancer screening in transgender women
    Maryam Sattari, MD, MS
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 721; DOI: https://doi.org/10.3949/ccjm.92c.12001
  • You have access
    All menopausal hormone therapy is not alike
    Henry H. Lindner, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 721-722; DOI: https://doi.org/10.3949/ccjm.92c.12002
  • You have access
    In reply: All menopausal hormone therapy is not alike
    Samantha F. Butts, MD, MSCE
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 722; DOI: https://doi.org/10.3949/ccjm.92c.12003
  • You have access
    Cystatin C for estimating glomerular filtration rate and guiding medication dosing
    Shahzeb Saeed, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 722-723; DOI: https://doi.org/10.3949/ccjm.92c.12004
  • You have access
    Corticosteroids in severe community-acquired pneumonia
    Enmanuel A. Leiva-Murillo, MD and Rosanel Amaro-Rodríguez, MD, PhD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 723-724; DOI: https://doi.org/10.3949/ccjm.92c.12005
  • You have access
    In Reply: Corticosteroids in severe community-acquired pneumonia
    Alejandro Chapa-Rodriguez, MD, Tark Abou-Elmagd, MD, Cody O’Rear, DO and Shraddha Narechania, MD
    Cleveland Clinic Journal of Medicine December 2025, 92 (12) 724; DOI: https://doi.org/10.3949/ccjm.92c.12006
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In this issue

Cleveland Clinic Journal of Medicine: 92 (12)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 12
1 Dec 2025
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Complete Issue (PDF)

Issue highlights

  • Latent autoimmune diabetes in adults: Not type 1, not type 2, a little of both
  • LADA: A case for starting insulin therapy at diagnosis
  • Should I consider low-dose rivaroxaban (2.5 mg) for my patient with peripheral artery disease?
  • Skin manifestations of mpox
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Finding the cause of severe hypokalemia: A 4-step approach
How should I incorporate emergency contraception counseling into my practice?
Acute transient phlebitis after a morphine infusion
Rethinking recovery in heart failure: Beyond improvement in left ventricular ejection fraction
Failure to thrive in hospitalized older adults: More than a ‘social admission’
What is the optimal time for bone density screening in patients with premature ovarian insufficiency?
No surprise, all inflammation is not created equal as it relates to cardiovascular disease
Benign migratory glossitis
Flexibility is warranted in applying prescribing guidelines
How can I help my pregnant patients quit using tobacco?
Half-moccasin distribution of acute tinea pedis
Cerebrovascular complications in infective endocarditis: Challenges and considerations in management
Evolving paradigms in hypertension management: Fixed-dose single-pill combinations and future therapies
Refractory granuloma annulare

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