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Interpreting Key Trials

Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation

Anže Djordjević, MD, PhD and Edward Soltesz, MD, MPH
Cleveland Clinic Journal of Medicine July 2025, 92 (7) 415-419; DOI: https://doi.org/10.3949/ccjm.92a.25001
Anže Djordjević
Department of Cardiac Surgery, University Medical Centre Maribor, Maribor, Slovenia
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  • For correspondence: [email protected]
Edward Soltesz
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Article Information

vol. 92 no. 7 415-419
DOI 
https://doi.org/10.3949/ccjm.92a.25001
PubMed 
40592537

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online July 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Anže Djordjević, MD, PhD⇑
  1. Department of Cardiac Surgery, University Medical Centre Maribor, Maribor, Slovenia
  1. Address:
    Anže Djordjević, MD, PhD, Department of Cardiac Surgery, University Medical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia; anze.djordjevic{at}ukc-mb.si
  1. Edward Soltesz, MD, MPH
  1. Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Cleveland Clinic Journal of Medicine: 92 (7)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 7
1 Jul 2025
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Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation
Anže Djordjević, Edward Soltesz
Cleveland Clinic Journal of Medicine Jul 2025, 92 (7) 415-419; DOI: 10.3949/ccjm.92a.25001

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Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation
Anže Djordjević, Edward Soltesz
Cleveland Clinic Journal of Medicine Jul 2025, 92 (7) 415-419; DOI: 10.3949/ccjm.92a.25001
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  • Article
    • ABSTRACT
    • OCCLUDE THE APPENDAGE, PREVENT A STROKE?
    • LAAOS III: A LARGE RANDOMIZED TRIAL
    • MODEST BUT MEANINGFUL BENEFIT
    • HOW WILL THIS CHANGE PRACTICE?
    • CONTROVERSIES AND UNANSWERED QUESTIONS
    • FUTURE RESEARCH DIRECTIONS
    • AN ADJUNCTIVE STRATEGY IN APPROPRIATE CASES
    • DISCLOSURES
    • Acknowledgments:
    • REFERENCES
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