Table of Contents
From the Editor
- Immunotherapy meets William Shakespeare
Immune checkpoint inhibitors are potentially life-saving therapies that can trigger a wide range of autoimmune pathology.
The Clinical Picture
- Odontogenic cutaneous fistula
A 55-year-old woman with a history of systemic lupus erythematosus and secondary Sjögren syndrome presented with a 2-year history of facial swelling and intermittent drainage from a skin lesion on her left jaw.
1-Minute Consult
- How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy?
Diarrhea and colitis, which can result from infection or be complications of immune checkpoint inhibitors, require prompt evaluation so that appropriate treatment can be started.
Interpreting Key Trials
- Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation
Left atrial appendage occlusion added to routine cardiac surgery reduced the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation and high stroke risk, but questions remain.
Review
Fecal microbiota transplantation: Current evidence and future directionsFecal microbiota transplantation is recognized for effectively treating recurrent Clostridioides difficile infection, prompting further investigation into its other possible clinical applications.
- Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelines
Recommendations for adjusting the treatment regimen of each class of noninsulin glucose-lowering agents before surgery are discussed.
- Breast cancer risk and screening for transgender and gender-diverse individuals
Evidence on breast cancer risk in transgender and gender-diverse individuals is limited, and recent guidelines are primarily based on expert consensus, retrospective cohort studies, and extrapolation from cisgender populations.
Commentary
The authors discuss evidence on the effects of legalized recreational cannabis on overall cannabis consumption, crime, traffic safety, and individual and community health.