Table of Contents
From the Editor
- Newer diabetes drugs: Surprising shared benefits and unique side effects
The shared beneficial effects of the SGLT2 inhibitors and the GLP-1 receptor agonists, drugs with distinct mechanisms of action, may have an anti-inflammatory explanation.
The Clinical Picture
- Refractory granuloma annulare
A 77-year-old woman presented with a rash characterized by orange-yellow papules coalescing into erythematous annular plaques on her hands, trunk, and legs.
1-Minute Consult
- Does my patient need testing for PFAS ‘forever chemicals’?
Any patient has the right to undergo blood testing for PFAS, but the limitations of testing must be discussed with the patient.
- Should I consider single-pill combination antihypertensive therapy for my patient with high blood pressure?
For many patients, starting treatment with a single-pill combination should be considered for the initial management of hypertension.
Editorial
- Evolving paradigms in hypertension management: Fixed-dose single-pill combinations and future therapies
Despite the availability of effective medications, blood pressure control rates have declined over the past decade, underscoring the need for improved treatment approaches.
Medical Grand Rounds
- The overlooked and undertreated perils of premature ovarian insufficiency
Physicians should be alert to the possibility of undiagnosed premature ovarian insufficiency—loss of ovarian function before age 40—and know what to do if the condition is suspected.
Review
- Glucagon-like peptide-1 receptor agonists and pancreatitis: A reconcilable divorce
Early trials suggested a link between GLP-1 receptor agonists and pancreatitis, but recent large meta-analyses do not support a class-wide risk.
Cerebrovascular complications in infective endocarditis: Challenges and considerations in managementAlthough the cerebrovascular complications of infective endocarditis such as ischemic strokes and intracranial hemorrhages are common and serious, data remain scarce regarding how best to prevent, predict, and manage them.
- Managing the side effects of sodium-glucose cotransporter-2 inhibitors
The authors review recent evidence on the side effects of sodium-glucose cotransporter-2 inhibitors and corresponding strategies for preventing and managing them.
