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Medical Grand Rounds

The overlooked and undertreated perils of premature ovarian insufficiency

Samantha F. Butts, MD, MSCE
Cleveland Clinic Journal of Medicine August 2025, 92 (8) 475-482; DOI: https://doi.org/10.3949/ccjm.92gr.25056
Samantha F. Butts
Chief, Division of Reproductive Endocrinology and Infertility, Penn State Health, Hershey, PA
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  • For correspondence: sbutts{at}pennstatehealth.psu.edu
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Article Information

vol. 92 no. 8 475-482
DOI 
https://doi.org/10.3949/ccjm.92gr.25056
PubMed 
40750321

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online August 1, 2025.

Copyright & Usage 
Copyright © 2025 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Samantha F. Butts, MD, MSCE⇑
  1. Chief, Division of Reproductive Endocrinology and Infertility, Penn State Health, Hershey, PA
  2. Vice Chair of Quality and Safety, Department of Obstetrics and Gynecology, Penn State Health, Hershey, PA
  3. Professor, Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, PA
  1. Address:
    Samantha F. Butts, MD, MSCE, Department of Obstetrics and Gynecology, 500 University Drive, Suite C3608, Hershey, PA 17033; sbutts{at}pennstatehealth.psu.edu

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Cleveland Clinic Journal of Medicine: 92 (8)
Cleveland Clinic Journal of Medicine
Vol. 92, Issue 8
1 Aug 2025
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The overlooked and undertreated perils of premature ovarian insufficiency
Samantha F. Butts
Cleveland Clinic Journal of Medicine Aug 2025, 92 (8) 475-482; DOI: 10.3949/ccjm.92gr.25056

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The overlooked and undertreated perils of premature ovarian insufficiency
Samantha F. Butts
Cleveland Clinic Journal of Medicine Aug 2025, 92 (8) 475-482; DOI: 10.3949/ccjm.92gr.25056
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  • Article
    • ABSTRACT
    • POI IS NOT MENOPAUSE
    • POI IS NOT AS RARE AS ONCE THOUGHT
    • POI HAS MAJOR HEALTH IMPLICATIONS
    • IN POI, HORMONE THERAPY IS PHYSIOLOGIC REPLACEMENT
    • UNCOVERING POI: A ROLE FOR PRIMARY CARE
    • CONCLUSION
    • DISCLOSURES
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    • REFERENCES
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