Table of Contents
From the Editor
- More on the myths and perceived magic of corticosteroids
It is widely accepted that corticosteroids can partially prevent infusion reactions to intravenous diagnostic and therapeutic agents, but evidence to support this concept is scant.
The Clinical Picture
- Multicentric reticulohistiocytosis
A 58-year-old man presented with a 2-month history of joint pain and swelling and a rash.
- Pseudoxanthoma elasticum
The patient presented for evaluation of yellowish plaques on her neck that had been present since childhood.
1-Minute Consult
- Atrial fibrillation in patients with obesity: How can we optimize management?
Heart rate and rhythm control therapies often must be adjusted when treating patients with obesity, while other measures can reduce the onset or recurrence of atrial fibrillation.
Symptoms to Diagnosis
- A young woman with Kallmann syndrome and acute neurologic symptoms
Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.
Current Drug Therapy
- Update on antiobesity pharmacotherapy in adults: Current and emerging options
The authors review antiobesity medications that are currently available or under investigation and discuss how to personalize obesity treatment.
Review
- Do corticosteroids prevent reactions to infusions of contrast, monoclonal antibodies, or chemotherapy?
The data and recommendations about corticosteroid pretreatment vary by medication class and the individual medication, necessitating a medication- and patient-specific approach.




Commentary
Vaccination recently was hailed as one of the top 10 public health achievements of the 20th century; now, the World Health Organization lists vaccine hesitancy among the top 10 threats to global health.