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1-Minute Consult

Should potassium-competitive acid blockers replace proton pump inhibitors as first-line therapy for patients with severe (Los Angeles grade C or D) esophagitis?

Sandra Elmasry, MD, Allon Kahn, MD, Lisa Marks, MLS, AHIP and Neera Agrwal, MD, PhD
Cleveland Clinic Journal of Medicine February 2026, 93 (2) 84-87; DOI: https://doi.org/10.3949/ccjm.93a.25044
Sandra Elmasry
Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
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  • For correspondence: elmasry.sandra{at}mayo.edu
Allon Kahn
Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ
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Lisa Marks
Division of Education, Department of Library Services, Mayo Clinic Arizona, Scottsdale, AZ
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Neera Agrwal
Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
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Article Information

vol. 93 no. 2 84-87
DOI 
https://doi.org/10.3949/ccjm.93a.25044
PubMed 
41629061

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online February 2, 2026.

Copyright & Usage 
Copyright © 2026 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Sandra Elmasry, MD⇑
  1. Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
  1. Address:
    Sandra Elmasry, MD, Division of Internal Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259; elmasry.sandra{at}mayo.edu
  1. Allon Kahn, MD
  1. Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ
  1. Lisa Marks, MLS, AHIP
  1. Division of Education, Department of Library Services, Mayo Clinic Arizona, Scottsdale, AZ
  1. Neera Agrwal, MD, PhD
  1. Division of Internal Medicine, Mayo Clinic Arizona, Scottsdale, AZ
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Cleveland Clinic Journal of Medicine: 93 (2)
Cleveland Clinic Journal of Medicine
Vol. 93, Issue 2
1 Feb 2026
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Should potassium-competitive acid blockers replace proton pump inhibitors as first-line therapy for patients with severe (Los Angeles grade C or D) esophagitis?
Sandra Elmasry, Allon Kahn, Lisa Marks, Neera Agrwal
Cleveland Clinic Journal of Medicine Feb 2026, 93 (2) 84-87; DOI: 10.3949/ccjm.93a.25044

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Should potassium-competitive acid blockers replace proton pump inhibitors as first-line therapy for patients with severe (Los Angeles grade C or D) esophagitis?
Sandra Elmasry, Allon Kahn, Lisa Marks, Neera Agrwal
Cleveland Clinic Journal of Medicine Feb 2026, 93 (2) 84-87; DOI: 10.3949/ccjm.93a.25044
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  • Article
    • WHAT IS ESOPHAGITIS, AND HOW IS IT GRADED?
    • HOW IS ESOPHAGITIS TREATED?
    • HOW DO PPIs WORK, AND WHAT ARE THE DRAWBACKS OF USING THEM TO TREAT ESOPHAGITIS?
    • WHAT ARE PCABs?
    • DO PCABs OUTPERFORM PPIs FOR HIGH-GRADE ESOPHAGITIS?
    • WHEN SHOULD WE USE A PCAB?
    • THE BOTTOM LINE
    • DISCLOSURES
    • REFERENCES
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  • Info & Metrics
  • PDF

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