Article Figures & Data
Tables
Indication Approved by US Food and Drug Administration to treat acute postoperative pain for 14 days Dose Loading: 100 mg
Maintenance: 50 mg every 12 hoursDuration Half-life of 23.6 hours Cost $15.50 per pill18 (typical course is 2 weeks) Common side effects Nausea and vomiting, pruritis, rash, muscle spasms, increased serum creatine phosphokinase level Contraindications Hormonal contraceptives: may impair efficacy
Cirrhosis: reduce dose for Child-Pugh class B; do not use in Child-Pugh class C
CYP3A substrates: inhibitors may cause accumulation of drug and metabolites; inducers may reduce effectBased on information from reference 11.






