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Symptoms to Diagnosis

Unexplained liver injury: Searching for the cause

Mohamed Eldib, MD, William D. Carey, MD and Blazenka Skugor, MD
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272; DOI: https://doi.org/10.3949/ccjm.93a.25099
Mohamed Eldib
Research Fellow, Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH
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  • For correspondence: eldibm{at}ccf.org
William D. Carey
Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Blazenka Skugor
Vice Chair, Department of Internal Medicine and Geriatrics, South Region; Section Head, Department of Internal Medicine and Geriatrics, Twinsburg Family Health and Surgery Center, Cleveland Clinic, Twinsburg, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Article Information

vol. 93 no. 5 267-272
DOI 
https://doi.org/10.3949/ccjm.93a.25099
PubMed 
42067224

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online May 1, 2026.

Copyright & Usage 
Copyright © 2026 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Mohamed Eldib, MD⇑
  1. Research Fellow, Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH
  1. Address:
    Mohamed Eldib, MD, Research Fellow, Department of Endocrinology, Diabetes, and Metabolism, F20, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; eldibm{at}ccf.org
  1. William D. Carey, MD
  1. Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Blazenka Skugor, MD
  1. Vice Chair, Department of Internal Medicine and Geriatrics, South Region; Section Head, Department of Internal Medicine and Geriatrics, Twinsburg Family Health and Surgery Center, Cleveland Clinic, Twinsburg, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Cleveland Clinic Journal of Medicine: 93 (5)
Cleveland Clinic Journal of Medicine
Vol. 93, Issue 5
1 May 2026
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Unexplained liver injury: Searching for the cause
Mohamed Eldib, William D. Carey, Blazenka Skugor
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272; DOI: 10.3949/ccjm.93a.25099

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Unexplained liver injury: Searching for the cause
Mohamed Eldib, William D. Carey, Blazenka Skugor
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 267-272; DOI: 10.3949/ccjm.93a.25099
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  • Article
    • EVALUATING OUT-OF-RANGE LABORATORY RESULTS
    • MORE TESTING IS NEEDED
    • CASE CONTINUED: LIVER INJURY PROGRESSES
    • NO OBSTRUCTION, NOW WHAT?
    • NARROWING THE DIAGNOSIS
    • CASE CONTINUED: IMAGING STUDIES AND LIVER BIOPSY
    • CASE CONCLUSION: IMPROVEMENT AFTER DRUG DISCONTINUATION
    • AMOXICILLIN-CLAVULANATE–INDUCED LIVER INJURY
    • TAKE-HOME POINTS
    • DISCLOSURES
    • REFERENCES
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  • PDF

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