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Review

Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight

Leandro Sierra, MD, Lily Liu, MD, Akash Khurana, MD, Roma Patel, MD, Arjun Chatterjee, MD, Stephen Firkins, MD and Roberto Simons-Linares, MD
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286; DOI: https://doi.org/10.3949/ccjm.93a.25082
Leandro Sierra
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
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Lily Liu
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
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  • For correspondence: liul12{at}ccf.org
Akash Khurana
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Roma Patel
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Arjun Chatterjee
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Stephen Firkins
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Roberto Simons-Linares
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Article Information

vol. 93 no. 5 279-286
DOI 
https://doi.org/10.3949/ccjm.93a.25082
PubMed 
42067225

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online May 1, 2026.

Copyright & Usage 
Copyright © 2026 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Leandro Sierra, MD
  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Lily Liu, MD⇑
  1. Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
  1. Address:
    Lily Liu, MD, Department of Internal Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; liul12{at}ccf.org
  1. Akash Khurana, MD
  1. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
  1. Roma Patel, MD
  1. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
  1. Arjun Chatterjee, MD
  1. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
  1. Stephen Firkins, MD
  1. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
  1. Roberto Simons-Linares, MD
  1. Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH
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Cleveland Clinic Journal of Medicine: 93 (5)
Cleveland Clinic Journal of Medicine
Vol. 93, Issue 5
1 May 2026
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Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
Leandro Sierra, Lily Liu, Akash Khurana, Roma Patel, Arjun Chatterjee, Stephen Firkins, Roberto Simons-Linares
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286; DOI: 10.3949/ccjm.93a.25082

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Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
Leandro Sierra, Lily Liu, Akash Khurana, Roma Patel, Arjun Chatterjee, Stephen Firkins, Roberto Simons-Linares
Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286; DOI: 10.3949/ccjm.93a.25082
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  • Article
    • ABSTRACT
    • METABOLIC-ASSOCIATED SYNDROMES ARE A GLOBAL PANDEMIC
    • DIET AND EXERCISE TO LOSE WEIGHT: EASIER SAID THAN DONE
    • GLP-1 RECEPTOR AGONISTS
    • GLP-1 AND GIP DUAL AGONISTS SHOW PROMISE
    • THE THYROID HORMONE RECEPTOR BETA AGONIST RESMETIROM
    • METABOLIC-BARIATRIC SURGERY
    • ENDOSCOPIC BARIATRIC AND METABOLIC THERAPIES
    • TAKE-HOME MESSAGE
    • DISCLOSURES
    • REFERENCES
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