Table of Contents

Activation of the immune system can be associated with many off-target manifestations.

While receiving an infusion of 10% calcium gluconate, the patient developed pain, swelling, and erythema at the catheter site.

The patient presented with conjunctivitis, skin rash, and oral and genital mucosal lesions 2 weeks after being ill with a fever, productive cough, and myalgia.

Reserve the test for scenarios where a plasma cell disorder is clinically suspected, and interpret mild elevations through the lenses of the kappa:lambda ratio and patient context.

Secondary headache disorders such as neoplasm or infection are more often suspected than detected, but neuroimaging is warranted when red-flag features are present.

Current efforts are focused on better identifying patients at high risk for Barrett esophagus as candidates for endoscopic screening and developing less invasive and cheaper detection methods.

The authors offer practical guidance on identifying pulmonary nodules that require surveillance, determining appropriate follow-up intervals, and deciding when specialist evaluation and intervention are needed.

How we communicate nodule findings to our patients can influence their perception and whether they agree with and adhere to recommendations.

Amid the opioid crisis, kratom use has grown for self-management of pain, mood symptoms, and opioid withdrawal.

There is much confusion about who is using kratom, what the drug does, and what we physicians should do about it.