More articles from From the Editor

  • No surprise, all inflammation is not created equal as it relates to cardiovascular disease

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine October 2025, 92 (10) 587-589;
    • DOI: https://doi.org/10.3949/ccjm.92b.10025
    • It is accepted that inflammation is an important component of atherosclerotic cardiovascular disease, but have we found the right inflammatory target for pharmacologic therapy?

  • Flexibility is warranted in applying prescribing guidelines

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine September 2025, 92 (9) 520-521;
    • DOI: https://doi.org/10.3949/ccjm.92b.09025
    • Discontinuation of benzodiazepines in chronic users may be associated with a small increase in mortality and a higher risk of adverse events, especially in the short term after cessation.

  • Newer diabetes drugs: Surprising shared benefits and unique side effects

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine August 2025, 92 (8) 457-458;
    • DOI: https://doi.org/10.3949/ccjm.92b.08025
    • The shared beneficial effects of the SGLT2 inhibitors and the GLP-1 receptor agonists, drugs with distinct mechanisms of action, may have an anti-inflammatory explanation.

  • Immunotherapy meets William Shakespeare

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine July 2025, 92 (7) 390-391;
    • DOI: https://doi.org/10.3949/ccjm.92b.07025
    • Immune checkpoint inhibitors are potentially life-saving therapies that can trigger a wide range of autoimmune pathology.

  • Allopurinol hypersensitivity is rare, bad, and partially avoidable, but allopurinol can still be used effectively

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine June 2025, 92 (6) 326-328;
    • DOI: https://doi.org/10.3949/ccjm.92b.06025
    • The shadow of the 1984 Hande et al guidelines still hangs over clinical decision-making when managing allopurinol dosing in patients with gout and chronic kidney disease.

  • The gift of lasting immunity

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine May 2025, 92 (5) 263-264;
    • DOI: https://doi.org/10.3949/ccjm.92b.05025
    • Measles vaccine–induced immunity, although not necessarily lifelong for all individuals, is quite durable.

  • Psychedelics in the medical toolbox?

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2025, 92 (4) 200-201;
    • DOI: https://doi.org/10.3949/ccjm.92b.04025
    • Given the historical association of psychedelics as “recreational” mind-altering compounds within countercultures of the 1960s and 1970s, their current introduction into several aspects of medical practice is a surprise to many.

  • All sulfa drugs are not created equal

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2025, 92 (3) 136-137;
    • DOI: https://doi.org/10.3949/ccjm.92b.03025
    • Misinformation about “sulfa allergy” can result in unnecessary avoidance of useful medications and the prescription of less effective alternatives.

  • Treating the thyroid: Trust the feedback loop

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine February 2025, 92 (2) 71-72;
    • DOI: https://doi.org/10.3949/ccjm.92b.02025
    • Studies show that, when testing to detect or monitor thyroid dysfunction, we order more free T3 and T4 levels than are necessary. We apparently should trust the thyroid-stimulating hormone feedback loop more than we do.

  • Sleep is like Rodney Dangerfield

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine January 2025, 92 (1) 9-10;
    • DOI: https://doi.org/10.3949/ccjm.92b.01025
    • Sleep quantity (and, in some cases, quality) has been shown to impact memory and learning, mood, appetite, and pain, yet many patients and clinicians do not give sleep the respect it deserves.