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COVID-19 Curbside Consults

New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response

Sirada Panupattanapong, MD and Elizabeth B. Brooks, MD, PhD
Cleveland Clinic Journal of Medicine June 2020, DOI: https://doi.org/10.3949/ccjm.87a.ccc039
Sirada Panupattanapong
Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s
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Elizabeth B. Brooks
Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s
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ABSTRACT

Since late April 2020, data regarding Kawasaki-like syndrome and hyperinflammatory response in children associated with COVID-19 has rapidly emerged. Much remains unknown about the risk factors, pathogenesis, prognosis, and specific therapy for this emerging manifestation of COVID-19 known as Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C is rare and early recognition is crucial though no standardized treatment guideline have been established. Worldwide collaboration will be important as more cases are recognized going forward.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
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  1. Sirada Panupattanapong, MD
  1. Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s
  1. Elizabeth B. Brooks, MD, PhD
  1. Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s

ABSTRACT

Since late April 2020, data regarding Kawasaki-like syndrome and hyperinflammatory response in children associated with COVID-19 has rapidly emerged. Much remains unknown about the risk factors, pathogenesis, prognosis, and specific therapy for this emerging manifestation of COVID-19 known as Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C is rare and early recognition is crucial though no standardized treatment guideline have been established. Worldwide collaboration will be important as more cases are recognized going forward.

  • Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.
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Cleveland Clinic Journal of Medicine: 88 (1)
Cleveland Clinic Journal of Medicine
Vol. 88, Issue 1
1 Jan 2021
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New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response
Sirada Panupattanapong, Elizabeth B. Brooks
Cleveland Clinic Journal of Medicine Jun 2020, DOI: 10.3949/ccjm.87a.ccc039

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New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response
Sirada Panupattanapong, Elizabeth B. Brooks
Cleveland Clinic Journal of Medicine Jun 2020, DOI: 10.3949/ccjm.87a.ccc039
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • WHAT IS TRUE KAWASAKI DISEASE?
    • WHAT IS CURRENTLY KNOWN ABOUT COVID-19 ASSOCIATED KAWASAKI-DISEASE-LIKE SYNDROME AND OTHER MANIFESTATIONS
    • MANAGEMENT OF MIS-C ASSOCIATED WITH COVID-19 INFECTION
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