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COVID-19 Curbside Consults

New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response

Sirada Panupattanapong, MD and Elizabeth B. Brooks, MD, PhD
Cleveland Clinic Journal of Medicine June 2020, DOI: https://doi.org/10.3949/ccjm.87a.ccc039
Sirada Panupattanapong
Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s
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Elizabeth B. Brooks
Center for Pediatric Rheumatology and Immunology, Cleveland Clinic Children’s
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    TABLE 1

    Case definition for Multisystem Inflammatory Syndrome in Children (MIS-C)

    An individual < 21 years presenting with
    • Fever,a laboratory evidence of inflammation,b and evidence of clinically severe illness requiring hospitalization, with multisystem (> 2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND
    • No alternative plausible diagnoses; AND
    • Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms
    Additional comments
    • Some individuals may fulfill full or partial criteria for Kawasaki disease but should be reported if they meet the case definition for MIS-C
    • Consider MIS-C in any pediatric death with evidence of SARS-CoV-2 infection
    • ↵a Fever > 38.0°C for ≥ 24 hours, or report of subjective fever lasting ≥ 24 hours.

    • ↵b Including, but not limited to, 1 or more of the following: an elevated C-reactive protein, erythrocyte sedimentation rate, fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase, or interleukin 6, elevated neutrophils, reduced lymphocytes and low albumin.

    • RT-PCR = reverse transcription polymerase chain reaction

      Reproduced from Centers for Disease Control and Prevention website.7

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Cleveland Clinic Journal of Medicine: 90 (2)
Cleveland Clinic Journal of Medicine
Vol. 90, Issue 2
1 Feb 2023
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New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response
Sirada Panupattanapong, Elizabeth B. Brooks
Cleveland Clinic Journal of Medicine Jun 2020, DOI: 10.3949/ccjm.87a.ccc039

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New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response
Sirada Panupattanapong, Elizabeth B. Brooks
Cleveland Clinic Journal of Medicine Jun 2020, DOI: 10.3949/ccjm.87a.ccc039
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • WHAT IS TRUE KAWASAKI DISEASE?
    • WHAT IS CURRENTLY KNOWN ABOUT COVID-19 ASSOCIATED KAWASAKI-DISEASE-LIKE SYNDROME AND OTHER MANIFESTATIONS
    • MANAGEMENT OF MIS-C ASSOCIATED WITH COVID-19 INFECTION
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More in this TOC Section

  • Update to COVID-19 serologic testing : FAQs and caveats
  • Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'
  • COVID-19 in older adults
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