Latest Articles

  • ‘Even when the wound is healed, the scar remains’

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine May 2026, 93 (5) 255-256;
    • DOI: https://doi.org/10.3949/ccjm.93b.05026

    • Persistent or repetitive inflammatory or ischemic insults to internal organs may lead to progressive scarring that culminates in organ failure.

  • Finding the cause of severe hypokalemia

    Philip S. Mehler, MD and Dennis Gibson, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198;
    • DOI: https://doi.org/10.3949/ccjm.93c.04001

  • In Reply: Finding the cause of severe hypokalemia

    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198;
    • DOI: https://doi.org/10.3949/ccjm.93c.04002

  • Palatal mass with an overlying white lesion

    Takuma Watanabe, DDS, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 199-200;
    • DOI: https://doi.org/10.3949/ccjm.93a.25050

    • The patient had no symptoms related to the mass, and computed tomography did not show any notable abnormalities.

  • ‘All that wheezes is not asthma’—a reminder that the physical examination

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195;
    • DOI: https://doi.org/10.3949/ccjm.93b.04026

    • In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

  • Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options

    Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205;
    • DOI: https://doi.org/10.3949/ccjm.93a.25052

    • In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • Treating perinatal mood and anxiety disorders: A call to action

    Lulu Zhao, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 207-209;
    • DOI: https://doi.org/10.3949/ccjm.93a.26002

    • Perinatal mood and anxiety disorders remain untreated in 3 of 4 affected individuals giving birth.

  • Interpreting the DIGIT-HF trial: Time for a new look at digitalis?

    Enmanuel A. Leiva-Murillo, MD, Oriol Ventosa-Blázquez, MD and Eduard Solé-González, MD, PhD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 218-226;
    • DOI: https://doi.org/10.3949/ccjm.93a.25098

    • Digitoxin reduced the risk of death or first hospitalization for heart failure in patients with symptomatic heart failure with reduced ejection fraction who were already being treated with guideline-directed medical therapy.

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    Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care

    CME Image
    Magnus Chun, MD, Amrit Narwan, MD, Ryan Parto, MD, Andrew John Cruz, MD, Jiayi Ge, MD, Zan Ferrin, DO, Namrita George, DO, Evelyn Kue, DO, Adam Khattak, DO, Vignan Manne, MD and Amber Champion, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 241-248;
    • DOI: https://doi.org/10.3949/ccjm.93a.25054

    • Gastrointestinal disorders are common in patients with diabetes mellitus and can be linked to diabetes itself, its complications, or medications used to treat it.

  • Complement inhibition: A whole new world

    Nicholas Salupo, DO, Korey Bartolomeo, DO, Elias Bassil, MD, Corey Cavanaugh, DO, Georges Nakhoul, MD, MEd, Jonathan Taliercio, DO and Ali Mehdi, MD, MEd
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 227-236;
    • DOI: https://doi.org/10.3949/ccjm.93a.25076

    • As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.

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