Latest Articles

  • Sex-specific risk factors for stroke in women: Focus on the 2024 AHA/ASA guideline
    Paru S. David, MD, MSCP, Hannah Nordhues, MD, MSCP and Suneela Vegunta, MD, MSCP
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 297-303; DOI: https://doi.org/10.3949/ccjm.93a.25049

    Sex-specific factors like adverse pregnancy outcomes and premature and early menopause play a critical and often underrecognized role in shaping lifetime stroke risk in women.

  • ‘Even when the wound is healed, the scar remains’
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 255-256; DOI: https://doi.org/10.3949/ccjm.93b.05026

    Persistent or repetitive inflammatory or ischemic insults to internal organs may lead to progressive scarring that culminates in organ failure.

  • Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
    Clonal hematopoiesis of indeterminate potential and heart disease: What every internist needs to know
    Ohad Oren, MD, MPH, Abhay Singh, MD, Hetty E. Carraway, MD, MBA, Luke J. Laffin, MD and Steven E. Nissen, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 289-295; DOI: https://doi.org/10.3949/ccjm.93a.26003

    Clonal hematopoiesis is increasingly recognized as a driver of different types of heart disease, including ischemic heart disease, heart failure, arrhythmias, and nonischemic cardiac inflammation.

  • Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
    CME article
    Leandro Sierra, MD, Lily Liu, MD, Akash Khurana, MD, Roma Patel, MD, Arjun Chatterjee, MD, Stephen Firkins, MD and Roberto Simons-Linares, MD
    Cleveland Clinic Journal of Medicine May 2026, 93 (5) 279-286; DOI: https://doi.org/10.3949/ccjm.93a.25082

    Weight loss of at least 10% is associated with fibrosis regression in most patients, but losing this amount of weight and keeping it off is challenging, making pharmacologic and procedural interventions essential tools in clinical practice.

  • A 20-year-old woman with a 9-year history of shortness of breath
    Jack Johnson, OMS-1, Karishma Lukose, MS4 and Mary C. Labanowski, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 211-217; DOI: https://doi.org/10.3949/ccjm.93a.25073

    The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.

  • Finding the cause of severe hypokalemia
    Philip S. Mehler, MD and Dennis Gibson, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198; DOI: https://doi.org/10.3949/ccjm.93c.04001
  • ‘All that wheezes is not asthma’—a reminder that the physical examination
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195; DOI: https://doi.org/10.3949/ccjm.93b.04026

    In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

  • Complement inhibition: A whole new world
    Nicholas Salupo, DO, Korey Bartolomeo, DO, Elias Bassil, MD, Corey Cavanaugh, DO, Georges Nakhoul, MD, MEd, Jonathan Taliercio, DO and Ali Mehdi, MD, MEd
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 227-236; DOI: https://doi.org/10.3949/ccjm.93a.25076

    As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.

  • Clinical application of the complement system: A historical perspective
    Adam J. Brown, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239; DOI: https://doi.org/10.3949/ccjm.93a.26014

    Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care
    Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care
    CME article
    Magnus Chun, MD, Amrit Narwan, MD, Ryan Parto, MD, Andrew John Cruz, MD, Jiayi Ge, MD, Zan Ferrin, DO, Namrita George, DO, Evelyn Kue, DO, Adam Khattak, DO, Vignan Manne, MD and Amber Champion, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 241-248; DOI: https://doi.org/10.3949/ccjm.93a.25054

    Gastrointestinal disorders are common in patients with diabetes mellitus and can be linked to diabetes itself, its complications, or medications used to treat it.

Pages