Latest Articles

  • Is the MTHFR gene mutation associated with thrombosis?
    Andrew Dhawan, MD, DPhil and Charis Eng, MD, PhD
    Cleveland Clinic Journal of Medicine November 2023, 90 (11) 661-663; DOI: https://doi.org/10.3949/ccjm.90a.23044

    Clinicians should educate patients with this common polymorphism about the lack of evidence for associated thrombotic risk, and instead focus on modifiable risk factors for thrombosis.

  • What is the role for terlipressin in hepatorenal syndrome?
    Stephanie N. Bass, PharmD, Aanchal Kapoor, MD and Christina C. Lindenmeyer, MD
    Cleveland Clinic Journal of Medicine November 2023, 90 (11) 664-667; DOI: https://doi.org/10.3949/ccjm.90a.23037

    The drug is recommended as a first-line treatment of hepatorenal syndrome-related acute kidney injury, but it is associated with respiratory failure, especially in the setting of albumin administration, and certain comorbidities may increase the risk.

  • Anchors away
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine November 2023, 90 (11) 652-653; DOI: https://doi.org/10.3949/ccjm.90b.11023

    Before you read this, I recommend that you read the interesting article in this issue by Prakash et al, part of our Symptoms to Diagnosis series.

  • Cirrhosis: Primary care approaches to screening, immunization, and lifestyle modifications
    Cirrhosis: Primary care approaches to screening, immunization, and lifestyle modifications
    Asim Kichloo, MD, Michael Aljadah, MD, Michael Albosta, MD, Zain El-Amir, MD, Ghazaleh Goldar, MD, Muhammed Zatmar Khan, MD, Dushyant Singh Dahiya, MD and Farah Wani, MD
    Cleveland Clinic Journal of Medicine November 2023, 90 (11) 693-701; DOI: https://doi.org/10.3949/ccjm.90a.21043

    The authors review management of cirrhosis and complications such as esophageal varices and hepatocellular carcinoma, as well as chemical and medication exposures.

  • Portopulmonary hypertension: A focused review for the internist
    Portopulmonary hypertension: A focused review for the internist
    Mamta S. Chhabria, MD, Leela Krishna Teja Boppana, MD, Gaurav Manek, MD and Adriano R. Tonelli, MD, MSc
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 632-639; DOI: https://doi.org/10.3949/ccjm.90a.23023

    Key aspects of screening, diagnosis, and treatment, and a review of the various pulmonary hemodynamic patterns encountered in patients with liver disease.

  • A new paradigm for adult ADHD
    Uche Nkanginieme, Medical student
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 592-593; DOI: https://doi.org/10.3949/ccjm.90c.10002
  • Should I start an SGLT-2 inhibitor in my patient with heart failure and chronic kidney disease?
    Richard Sekerak, MD, Johanna Ben-Ami Lerner, MD, Pooja Prasad, MD and Megha Prasad, MD
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 607-609; DOI: https://doi.org/10.3949/ccjm.90a.23004

    These conditions often co-exist and can have complex interactions. The progression of kidney disease increases the risk of major adverse cardiovascular events.

  • Evaluating a low anion gap: A practical approach
    Lawrence A. Haber, MD, Gurpreet Dhaliwal, MD, Lowell Lo, MD and Gabrielle Rizzuto, MD, PhD
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 619-623; DOI: https://doi.org/10.3949/ccjm.90a.23035

    In teaching and in practice, little attention is given to a low anion gap, an oversight that can result in a missed opportunity to diagnose acute or chronic disorders requiring treatment.

  • Should midodrine be used as an intravenous vasopressor-sparing agent in septic shock?
    Simran Gupta, MD, Ayan Sen, MD and Aman Verma, DO
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 603-605; DOI: https://doi.org/10.3949/ccjm.90a.23040

    Research and robust data are still lacking regarding use of midodrine in this setting.

  • vOka vaccine-associated disseminated varicella zoster
    Peter R. Hyson, MD and Louis B. Polish, MD
    Cleveland Clinic Journal of Medicine October 2023, 90 (10) 599-600; DOI: https://doi.org/10.3949/ccjm.90a.23008

    The patient had received the live attenuated vaccine 1 month before presentation. He had no history of varicella infection.

Pages