Latest Articles
- Reversing fibrosis in metabolic dysfunction–associated steatohepatitis—beyond telling patients to lose weight
Weight loss of at least 10% is associated with fibrosis regression in most patients, but losing this amount of weight and keeping it off is challenging, making pharmacologic and procedural interventions essential tools in clinical practice.
- Palatal mass with an overlying white lesion
The patient had no symptoms related to the mass, and computed tomography did not show any notable abnormalities.
- Interpreting the DIGIT-HF trial: Time for a new look at digitalis?
Digitoxin reduced the risk of death or first hospitalization for heart failure in patients with symptomatic heart failure with reduced ejection fraction who were already being treated with guideline-directed medical therapy.
- Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options
In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.
- A 20-year-old woman with a 9-year history of shortness of breath
The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.
- ‘All that wheezes is not asthma’—a reminder that the physical examination
In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.
- Complement inhibition: A whole new world
As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.
- Clinical application of the complement system: A historical perspective
Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.