Latest Articles

  • Should I consider single-pill combination antihypertensive therapy for my patient with high blood pressure?
    Maximilian C. Volk, DO, Ahmad Safdar, MD and Luke J. Laffin, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 467-470; DOI: https://doi.org/10.3949/ccjm.92a.25002

    For many patients, starting treatment with a single-pill combination should be considered for the initial management of hypertension.

  • Glucagon-like peptide-1 receptor agonists and pancreatitis: A reconcilable divorce
    CME article
    Adi E. Mehta, MD, Laura D. Lomeli, BA and Kevin M. Pantalone, DO, ECNU
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 483-489; DOI: https://doi.org/10.3949/ccjm.92a.24113

    Early trials suggested a link between GLP-1 receptor agonists and pancreatitis, but recent large meta-analyses do not support a class-wide risk.

  • Newer diabetes drugs: Surprising shared benefits and unique side effects
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 457-458; DOI: https://doi.org/10.3949/ccjm.92b.08025

    The shared beneficial effects of the SGLT2 inhibitors and the GLP-1 receptor agonists, drugs with distinct mechanisms of action, may have an anti-inflammatory explanation.

  • Breast cancer risk and screening for transgender and gender-diverse individuals
    CME article
    Dzhuliyan V. Vasilev, MD, MMSc, Juliana M. Kling, MD, MPH and Evelyn F. Carroll, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 439-447; DOI: https://doi.org/10.3949/ccjm.92a.24088

    Evidence on breast cancer risk in transgender and gender-diverse individuals is limited, and recent guidelines are primarily based on expert consensus, retrospective cohort studies, and extrapolation from cisgender populations.

  • Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation
    Anže Djordjević, MD, PhD and Edward Soltesz, MD, MPH
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 415-419; DOI: https://doi.org/10.3949/ccjm.92a.25001

    Left atrial appendage occlusion added to routine cardiac surgery reduced the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation and high stroke risk, but questions remain.

  • How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy?
    Rupayan Kundu, MD, Arjun Chatterjee, MD, Jessica Philpott, MD, PhD and Lucy Boyce Kennedy, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 401-405; DOI: https://doi.org/10.3949/ccjm.92a.24090

    Diarrhea and colitis, which can result from infection or be complications of immune checkpoint inhibitors, require prompt evaluation so that appropriate treatment can be started.

  • Fecal microbiota transplantation: Current evidence and future directions
    Fecal microbiota transplantation: Current evidence and future directions
    Michael Cymbal, DO, Arjun Chatterjee, MD and Brian Baggott, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 421-428; DOI: https://doi.org/10.3949/ccjm.92a.24107

    Fecal microbiota transplantation is recognized for effectively treating recurrent Clostridioides difficile infection, prompting further investigation into its other possible clinical applications.

  • Recreational cannabis legalization: Potential implications for individual and community health
    Taseen Alam, BA, Connor Riegal, BS, Natalie Saadeh, MD, Fernanda Gushken, MD, MS, Hannah Snyder, MD, Brenden Jenks, MD and Akhil Anand, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 407-413; DOI: https://doi.org/10.3949/ccjm.92a.24086

    The authors discuss evidence on the effects of legalized recreational cannabis on overall cannabis consumption, crime, traffic safety, and individual and community health.

  • Managing right ventricular failure in the setting of pulmonary embolism
    Anup Katyal, MD and Ashwani Joshi, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 396; DOI: https://doi.org/10.3949/ccjm.92c.07003
  • Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelines
    Oscar L. Morey-Vargas, MD, Mona Gossmann, MD, Jeffrey M. Ketz, PharmD and Basem B. Abdelmalak, MD
    Cleveland Clinic Journal of Medicine July 2025, 92 (7) 429-437; DOI: https://doi.org/10.3949/ccjm.92a.24118

    Recommendations for adjusting the treatment regimen of each class of noninsulin glucose-lowering agents before surgery are discussed.

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