Latest Articles

  • A 20-year-old woman with a 9-year history of shortness of breath

    Jack Johnson, OMS-1, Karishma Lukose, MS4 and Mary C. Labanowski, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 211-217;
    • DOI: https://doi.org/10.3949/ccjm.93a.25073

    • The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.

  • Clinical application of the complement system: A historical perspective

    Adam J. Brown, MD
    • Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239;
    • DOI: https://doi.org/10.3949/ccjm.93a.26014

    • Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • ‘Boxing glove’ hands in a patient initially diagnosed with RS3PE syndrome

    Hirokazu Takai, MD and Seiko Takai, MD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 135-137;
    • DOI: https://doi.org/10.3949/ccjm.93a.25059

    • The patient had edema that limited finger flexion, impairing daily tasks such as putting on socks.

  • Ogilvie syndrome (colonic pseudo-obstruction)

    Mohamed Adam Ali, MBBS, BSc, Zahra Al-Badry and Fatima M. H. Ali, MBBS, MRCPCH
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 145-146;
    • DOI: https://doi.org/10.3949/ccjm.93a.21118

    • Two days after the patient underwent surgery to repair a left femur fracture, his abdomen became markedly distended, but without pain.

  • Westermark sign (focal oligemia) in pulmonary embolism

    Yusuke Namba, MD, PhD and Yusuke Kawai, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 149-150;
    • DOI: https://doi.org/10.3949/ccjm.93a.25051

    • The patient’s chest radiograph showed a focal area of reduced blood flow in the middle and upper zones of the right lung.

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    Polycystic ovary syndrome: An update on diagnosis and management

    Nayoung Sung, MD, MSCP, Jawaria Amir, MD, Ula Abed Alwahab, MD and Tommaso Falcone, MD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 176-183;
    • DOI: https://doi.org/10.3949/ccjm.93a.25090

    • Because this syndrome affects health throughout the lifespan, long-term management is essential, not only to control symptoms but also to prevent associated metabolic conditions.

  • A 24-year-old man with severe hemolytic anemia and variable Coombs test results

    Sindu Iska, MD, María Herrán, MD, You Li, MD, Maria Teresa Bejarano, MD, Chakra P. Chaulagain, MD and Chieh-Lin Fu, MD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 159-168;
    • DOI: https://doi.org/10.3949/ccjm.93a.25079

    • The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.

  • Alpha-1 antitrypsin deficiency: A persistently underrecognized condition

    James K. Stoller, MD, MS
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 153-157;
    • DOI: https://doi.org/10.3949/ccjm.93a.25103

    • Detecting alpha-1 antitrypsin deficiency early is imperative because diagnostic delay is associated with harm, including worsened clinical status and impaired survival.

  • Getting stuck on a name: An example of an eponymous syndrome

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 131-132;
    • DOI: https://doi.org/10.3949/ccjm.93b.03026

    • Debate continues about whether we should continue to use eponymous diagnostic nomenclature or shift entirely to an anatomic or pathophysiologic descriptive terminology.

  • Optimizing bowel preparation for colonoscopy: Updated consensus recommendations

    CME Image
    Hussam Kawas, MD and Claire Beveridge, MD
    • Cleveland Clinic Journal of Medicine March 2026, 93 (3) 169-175;
    • DOI: https://doi.org/10.3949/ccjm.93a.25086

    • Key updates in the 2025 guideline include simplifying dietary restrictions to low-residue foods for a single day before colonoscopy, preferring 2-L over 4-L preparation regimens, and universally recommending split-dose administration.

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