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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine

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Latest Articles

  • You have access
    ‘All that wheezes is not asthma’—a reminder that the physical examination
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 193-195; DOI: https://doi.org/10.3949/ccjm.93b.04026

    In the evaluation of a patient with undefined respiratory symptoms, the physical examination can provide clues to the diagnosis and direct further testing.

  • You have access
    Complement inhibition: A whole new world
    Nicholas Salupo, DO, Korey Bartolomeo, DO, Elias Bassil, MD, Corey Cavanaugh, DO, Georges Nakhoul, MD, MEd, Jonathan Taliercio, DO and Ali Mehdi, MD, MEd
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 227-236; DOI: https://doi.org/10.3949/ccjm.93a.25076

    As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.

  • You have access
    Clinical application of the complement system: A historical perspective
    Adam J. Brown, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 237-239; DOI: https://doi.org/10.3949/ccjm.93a.26014

    Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.

  • Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care
    You have access
    Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care
    CME article
    Magnus Chun, MD, Amrit Narwan, MD, Ryan Parto, MD, Andrew John Cruz, MD, Jiayi Ge, MD, Zan Ferrin, DO, Namrita George, DO, Evelyn Kue, DO, Adam Khattak, DO, Vignan Manne, MD and Amber Champion, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 241-248; DOI: https://doi.org/10.3949/ccjm.93a.25054

    Gastrointestinal disorders are common in patients with diabetes mellitus and can be linked to diabetes itself, its complications, or medications used to treat it.

  • You have access
    Treating perinatal mood and anxiety disorders: A call to action
    Lulu Zhao, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 207-209; DOI: https://doi.org/10.3949/ccjm.93a.26002

    Perinatal mood and anxiety disorders remain untreated in 3 of 4 affected individuals giving birth.

  • You have access
    Palatal mass with an overlying white lesion
    Takuma Watanabe, DDS, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 199-200; DOI: https://doi.org/10.3949/ccjm.93a.25050

    The patient had no symptoms related to the mass, and computed tomography did not show any notable abnormalities.

  • You have access
    In Reply: Finding the cause of severe hypokalemia
    Enmanuel A. Leiva-Murillo, MD, Erwin Bechtold-Javier, MD, Pol Candela-Parrilla, MD and Ana Matas-García, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 198; DOI: https://doi.org/10.3949/ccjm.93c.04002
  • You have access
    Interpreting the DIGIT-HF trial: Time for a new look at digitalis?
    Enmanuel A. Leiva-Murillo, MD, Oriol Ventosa-Blázquez, MD and Eduard Solé-González, MD, PhD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 218-226; DOI: https://doi.org/10.3949/ccjm.93a.25098

    Digitoxin reduced the risk of death or first hospitalization for heart failure in patients with symptomatic heart failure with reduced ejection fraction who were already being treated with guideline-directed medical therapy.

  • You have access
    Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options
    Rebeca Ortiz Worthington, MD, MS, CLC, Zehra Aftab, MD, Nicole Leong, MD, MS and Jason Alexander, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 201-205; DOI: https://doi.org/10.3949/ccjm.93a.25052

    In a guideline update, the American College of Obstetricians and Gynecologists now recommends using pharmacotherapy to treat perinatal depression, with selective serotonin reuptake inhibitors as first-line medications.

  • You have access
    A 20-year-old woman with a 9-year history of shortness of breath
    Jack Johnson, OMS-1, Karishma Lukose, MS4 and Mary C. Labanowski, MD
    Cleveland Clinic Journal of Medicine April 2026, 93 (4) 211-217; DOI: https://doi.org/10.3949/ccjm.93a.25073

    The patient had been given diagnoses of bronchitis, asthma, and COVID-19, and was previously treated with antibiotics as well as inhaled bronchodilators and steroids.

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