Latest Articles

  • Should I start anticoagulation in my patient newly diagnosed with pulmonary hypertension?
    Tark Abou-Elmagd, MD, MSc, MBBCh and Shraddha Narechania, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 339-343; DOI: https://doi.org/10.3949/ccjm.92a.24083

    The decision hinges on the subtype of pulmonary hypertension the patient has.

  • Amoxicillin rash in infectious mononucleosis
    Yasuhiro Kano, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 335-337; DOI: https://doi.org/10.3949/ccjm.92a.24039

    A 23-year-old woman developed a rash on the day she completed a 10-day course of amoxicillin for group A streptococcal infection.

  • High-output heart failure from arteriovenous dialysis access: A structured approach to diagnosis and management
    Maximilian C. Volk, DO, Bianca Honnekeri, MD, Joanna Ghobrial, MD, Mazen Hanna, MD, Sanjeeb Bhattacharya, MD, Lee Kirksey, MD, J. Emanuel Finet, MD and Heba Wassif, MD, MPH
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 362-371; DOI: https://doi.org/10.3949/ccjm.92a.24114

    Arteriovenous high-output heart failure is likely underdiagnosed because many clinicians are uncertain about when and how to evaluate for it.

  • Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice
    CME article
    Syed Bukhari, MD, MHA, Mohamed Ghoweba, MD, Syed Zamrak Khan, MD, Ammar Saati, MD and Marcelo Gomes, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 353-361; DOI: https://doi.org/10.3949/ccjm.92a.24061

    Preapproval trials of direct oral anticoagulants excluded patients with extreme body weight and advanced kidney and liver disease and those who had undergone bariatric surgery. Cautious decision-making in these patients is warranted.

  • My adult patient’s hypercholesterolemia is not responding to statins—what’s next?
    Faaiq N. Aslam, MD, Mohamed G. Ibrahim, DO and Razvan Chirila, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 347-351; DOI: https://doi.org/10.3949/ccjm.92a.24117

    Further investigation is needed when patients do not meet their target low-density lipoprotein cholesterol levels with statin therapy alone.

  • Nitrogen: The unsung hero of vascular physiology
    Adam J. Brown, MD
    Cleveland Clinic Journal of Medicine June 2025, 92 (6) 344-346; DOI: https://doi.org/10.3949/ccjm.92a.24120

    The seventh element on the periodic table—nitrogen—may not come to mind often in day-to-day medical practice, but it is more exciting than you might think.

  • The gift of lasting immunity
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 263-264; DOI: https://doi.org/10.3949/ccjm.92b.05025

    Measles vaccine–induced immunity, although not necessarily lifelong for all individuals, is quite durable.

  • Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
    Zehra Naseem, MD, Aun Muhammad, MD, Arjun Chatterjee, MD and Alberto Rubio-Tapia, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: https://doi.org/10.3949/ccjm.92a.24072

    Alpha-gal syndrome is an emerging allergic condition in which immunoglobulin E–mediated symptoms are triggered a few hours after an affected person consumes mammalian meat.

  • Managing right ventricular failure in the setting of pulmonary embolism
    Managing right ventricular failure in the setting of pulmonary embolism
    Sharmeen Sorathia, MD, Anibelky Almanzar, MD, Abhishek Bhandiwad, MD and Phoo Pwint Nandar, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 301-309; DOI: https://doi.org/10.3949/ccjm.92a.24069

    The authors review current management strategies, including medical, percutaneous interventional, and surgical options, and discuss recent advances in the field.

  • The beat goes on: Highlights from the new American and European A-fib guidelines
    Sandra Howell, MBBS, MEd, MSc, MPhil, Alphonsus Liew, MBBS and Christopher Aldo Rinaldi, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 297-300; DOI: https://doi.org/10.3949/ccjm.92a.25030

    The authors discuss and compare the latest atrial fibrillation guidelines from American and European medical societies.

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