Latest Articles
- Complement inhibition: A whole new world
As these medications enter the mainstream, understanding the complement system and the benefits and risks of therapeutic blockade has become crucial for optimal patient care.
- Clinical application of the complement system: A historical perspective
Now that our understanding of complement has evolved to therapeutic targeting of components of the cascade in a wide range of diseases, it is time to give the complement system another look.
- A 24-year-old man with severe hemolytic anemia and variable Coombs test results
The patient was admitted to the hospital because of dark urine, jaundice, fatigue, and confusion.
- Getting stuck on a name: An example of an eponymous syndrome
Debate continues about whether we should continue to use eponymous diagnostic nomenclature or shift entirely to an anatomic or pathophysiologic descriptive terminology.
- ‘Boxing glove’ hands in a patient initially diagnosed with RS3PE syndrome
The patient had edema that limited finger flexion, impairing daily tasks such as putting on socks.
- Alpha-1 antitrypsin deficiency: A persistently underrecognized condition
Detecting alpha-1 antitrypsin deficiency early is imperative because diagnostic delay is associated with harm, including worsened clinical status and impaired survival.
- Optimizing bowel preparation for colonoscopy: Updated consensus recommendations
Key updates in the 2025 guideline include simplifying dietary restrictions to low-residue foods for a single day before colonoscopy, preferring 2-L over 4-L preparation regimens, and universally recommending split-dose administration.
- Westermark sign (focal oligemia) in pulmonary embolism
The patient’s chest radiograph showed a focal area of reduced blood flow in the middle and upper zones of the right lung.
- Ogilvie syndrome (colonic pseudo-obstruction)
Two days after the patient underwent surgery to repair a left femur fracture, his abdomen became markedly distended, but without pain.
Polycystic ovary syndrome: An update on diagnosis and managementBecause this syndrome affects health throughout the lifespan, long-term management is essential, not only to control symptoms but also to prevent associated metabolic conditions.
