Latest Articles

  • The gift of lasting immunity
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 263-264; DOI: https://doi.org/10.3949/ccjm.92b.05025

    Measles vaccine–induced immunity, although not necessarily lifelong for all individuals, is quite durable.

  • Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy
    Zehra Naseem, MD, Aun Muhammad, MD, Arjun Chatterjee, MD and Alberto Rubio-Tapia, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 311-319; DOI: https://doi.org/10.3949/ccjm.92a.24072

    Alpha-gal syndrome is an emerging allergic condition in which immunoglobulin E–mediated symptoms are triggered a few hours after an affected person consumes mammalian meat.

  • Managing right ventricular failure in the setting of pulmonary embolism
    Managing right ventricular failure in the setting of pulmonary embolism
    Sharmeen Sorathia, MD, Anibelky Almanzar, MD, Abhishek Bhandiwad, MD and Phoo Pwint Nandar, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 301-309; DOI: https://doi.org/10.3949/ccjm.92a.24069

    The authors review current management strategies, including medical, percutaneous interventional, and surgical options, and discuss recent advances in the field.

  • The beat goes on: Highlights from the new American and European A-fib guidelines
    Sandra Howell, MBBS, MEd, MSc, MPhil, Alphonsus Liew, MBBS and Christopher Aldo Rinaldi, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 297-300; DOI: https://doi.org/10.3949/ccjm.92a.25030

    The authors discuss and compare the latest atrial fibrillation guidelines from American and European medical societies.

  • What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?
    Karthik Meiyappan Udayappan, MD and Christopher V. Anstine, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 273-276; DOI: https://doi.org/10.3949/ccjm.92a.24052

    Computed tomography of the patient’s chest is indicated based on the robust association between clubbing and intrathoracic malignancy.

  • Tinea incognito
    Soniya Shony, MBBS, Carol Lobo, MBBS, MD and Sowmya Kaimal, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 271-272; DOI: https://doi.org/10.3949/ccjm.92a.24099

    This atypical form of dermatophyte infection is caused by local immune suppression from systemic or topical corticosteroids.

  • New atrial fibrillation guideline: Modify risk, control rhythm, prevent progression
    CME article
    Laura A. Campbell, MD, Jessica P. Ammon, DO, Rachana Kombathula, MD, Naa’irah Muhammad, MD and Christopher D. Jackson, MD
    Cleveland Clinic Journal of Medicine May 2025, 92 (5) 291-296; DOI: https://doi.org/10.3949/ccjm.92a.24067

    Key updates in the new American guideline include recommendations for aggressive lifestyle and risk-factor modifications, annual assessment of thromboembolic risk, and early rhythm control.

  • Subclinical hypothyroidism: What’s in a name?
    Jennifer S. Mammen, MD, PhD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 233-235; DOI: https://doi.org/10.3949/ccjm.92a.25028

    Clinicians should remain thoughtful about the variability in aging biology and not be blinded by a name.

  • Psychedelics, spirituality, and existential distress in patients at the end of life
    Nicole Cornish, PharmD, Tara Coles, MD, M. Jennifer Cheng, MD, Claudia Ruiz Sotomayor, MD, DBe, Aaron Wolfgang, MD and Christopher Spevak, MD, MPH, JD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 248-254; DOI: https://doi.org/10.3949/ccjm.92a.24100

    The authors explore the role of psychedelics in addressing patients’ spiritual and existential suffering at the end of life from a medical, ethical, and legal perspective.

  • Prolonged venous filling time and dependent rubor in a patient with peripheral artery disease
    Scott L. Hagan, MD and Jeffrey W. Redinger, MD
    Cleveland Clinic Journal of Medicine April 2025, 92 (4) 205-206; DOI: https://doi.org/10.3949/ccjm.92a.24056

    Physical examination in a man who presented with foot pain revealed absent bilateral posterior tibial and dorsalis pedis pulses and dusky erythema of both feet.

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