Latest Articles

  • How can I help my pregnant patients quit using tobacco?
    Moronkeji Fagbemi, MD, Ivie Odiase, MD and Anna Fagbemi, MD
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 542-545; DOI: https://doi.org/10.3949/ccjm.92a.25008

    Clinicians should screen for tobacco use and follow-up with pregnancy-specific messaging during each visit, building on any motivation the patient has to quit.

  • What is the role of cystatin C in estimating glomerular filtration rate and guiding medication dosing?
    Joseph Hajj, MD, Allaa Almoushref, MD, Georges Nakhoul, MD and George Thomas, MD
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 546-549; DOI: https://doi.org/10.3949/ccjm.92a.25036

    A dual-marker strategy using both serum creatinine and cystatin C is recommended for certain patients in whom serum creatinine alone may not accurately reflect kidney function.

  • Optimizing hypertension treatment: Evidence-based approaches and new drugs
    CME article
    Astefanos Al-Dalakta, MD, Ahmad Ghanem, MD, Chadi Tabaja, MD, Issam Motairek, MD, Abdel Hadi El Hajjar, MD and Luke J. Laffin, MD
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 555-564; DOI: https://doi.org/10.3949/ccjm.92a.24119

    The authors discuss current evidence-based approaches to managing hypertension and optimizing blood pressure control through a series of cases representing common clinical scenarios.

  • Acute respiratory distress syndrome: Why a definition matters
    Acute respiratory distress syndrome: Why a definition matters
    Christine Girard, MD, Divyajot Sadana, MD, Shewit Giovanni, MD, MS, Heather Torbic, PharmD, BCPS, BCCCP and Abhijit Duggal, MD, MPH, MSc
    Cleveland Clinic Journal of Medicine September 2025, 92 (9) 565-571; DOI: https://doi.org/10.3949/ccjm.92a.24115

    The new definition brings acute respiratory distress syndrome into the realm of physicians working on hospital general medicine wards.

  • Refractory granuloma annulare
    Mery Deeb, MD and Hadeel Zainah, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 461; DOI: https://doi.org/10.3949/ccjm.92a.24043

    A 77-year-old woman presented with a rash characterized by orange-yellow papules coalescing into erythematous annular plaques on her hands, trunk, and legs.

  • Managing the side effects of sodium-glucose cotransporter-2 inhibitors
    Nandan Kodur, BS, Betemariam Sharew, BA, M. Cecilia Lansang, MD, MPH and W. H. Wilson Tang, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 503-511; DOI: https://doi.org/10.3949/ccjm.92a.24071

    The authors review recent evidence on the side effects of sodium-glucose cotransporter-2 inhibitors and corresponding strategies for preventing and managing them.

  • The overlooked and undertreated perils of premature ovarian insufficiency
    Samantha F. Butts, MD, MSCE
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 475-482; DOI: https://doi.org/10.3949/ccjm.92gr.25056

    Physicians should be alert to the possibility of undiagnosed premature ovarian insufficiency—loss of ovarian function before age 40—and know what to do if the condition is suspected.

  • Cerebrovascular complications in infective endocarditis: Challenges and considerations in management
    Cerebrovascular complications in infective endocarditis: Challenges and considerations in management
    Vikyath Satish, MD, Maisha Maliha, MD, Abhyuday Chauhan, MD, Nieves del Mar Morales-Gomez, MD, Safwan Gaznabi, MD, Daniel Lorenzatti, MD, Justin Johannesen, MD, Carlos A. Gongora, MD, Annalisa Filtz, MD, Mario J. Garcia, MD, Leandro Slipczuk, MD, PhD and Aldo L. Schenone, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 491-501; DOI: https://doi.org/10.3949/ccjm.92a.24087

    Although the cerebrovascular complications of infective endocarditis such as ischemic strokes and intracranial hemorrhages are common and serious, data remain scarce regarding how best to prevent, predict, and manage them.

  • Evolving paradigms in hypertension management: Fixed-dose single-pill combinations and future therapies
    George Thomas, MD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 471-474; DOI: https://doi.org/10.3949/ccjm.92a.25034

    Despite the availability of effective medications, blood pressure control rates have declined over the past decade, underscoring the need for improved treatment approaches.

  • Does my patient need testing for PFAS ‘forever chemicals’?
    Philip Zuccaro, BS, Damaskini Valvi, MD, MPH, PhD and Vasilis Vasiliou, PhD
    Cleveland Clinic Journal of Medicine August 2025, 92 (8) 463-465; DOI: https://doi.org/10.3949/ccjm.92a.24082

    Any patient has the right to undergo blood testing for PFAS, but the limitations of testing must be discussed with the patient.

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