Latest Articles
- Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice
Preapproval trials of direct oral anticoagulants excluded patients with extreme body weight and advanced kidney and liver disease and those who had undergone bariatric surgery. Cautious decision-making in these patients is warranted.
- My adult patient’s hypercholesterolemia is not responding to statins—what’s next?
Further investigation is needed when patients do not meet their target low-density lipoprotein cholesterol levels with statin therapy alone.
- Nitrogen: The unsung hero of vascular physiology
The seventh element on the periodic table—nitrogen—may not come to mind often in day-to-day medical practice, but it is more exciting than you might think.
IgA nephropathy: Update on pathogenesis and treatmentRenin-angiotensin-aldosterone system inhibitors or corticosteroids remain the cornerstone of therapy, but new agents targeting the different “hits” in the pathogenesis of IgA nephropathy are being introduced.
- Severe cutaneous reaction induced by allopurinol
Three weeks after starting allopurinol for gout, an 86-year-old woman presented with a maculopapular rash and painful blistering and erosions of the oral mucosa.
- Allopurinol hypersensitivity is rare, bad, and partially avoidable, but allopurinol can still be used effectively
The shadow of the 1984 Hande et al guidelines still hangs over clinical decision-making when managing allopurinol dosing in patients with gout and chronic kidney disease.
- Managing right ventricular failure in the setting of pulmonary embolism
The authors review current management strategies, including medical, percutaneous interventional, and surgical options, and discuss recent advances in the field.
- The beat goes on: Highlights from the new American and European A-fib guidelines
The authors discuss and compare the latest atrial fibrillation guidelines from American and European medical societies.
- What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?
Computed tomography of the patient’s chest is indicated based on the robust association between clubbing and intrathoracic malignancy.
- Tinea incognito
This atypical form of dermatophyte infection is caused by local immune suppression from systemic or topical corticosteroids.
