TY - JOUR T1 - Recurrent <em>Clostridioides difficile</em> infection: Recognition, management, prevention JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 347 LP - 359 DO - 10.3949/ccjm.87gr.20001 VL - 87 IS - 6 AU - Constantine Tsigrelis Y1 - 2020/06/01 UR - http://www.ccjm.org/content/87/6/347.abstract N2 - Clostridioides difficile infection (CDI) is the most common cause of diarrhea in hospitalized patients and results in substantial morbidity, mortality, and costs. Its clinical management, primarily with antibiotics, is often complicated by recurrent episodes. These recurrent CDI episodes are thought to be caused by antibiotic disruption of colonic microbiota and usually occur within 4 weeks of completing antibiotic therapy. The risk of recurrent CDI increases after the first episode, creating a need for management strategies to diagnose, treat, and prevent these complications. ER -