%0 Journal Article %A Seth R. Bauer %A Aanchal Kapoor %A Mary Rath %A Suma A. Thomas %T What is the role of supplementation with ascorbic acid, zinc, vitamin D, or N-acetylcysteine for prevention or treatment of COVID-19? %D 2020 %R 10.3949/ccjm.87a.ccc046 %J Cleveland Clinic Journal of Medicine %X Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents. %U https://www.ccjm.org/content/ccjom/early/2020/06/08/ccjm.87a.ccc046.full.pdf