PT - JOURNAL ARTICLE AU - Seth R. Bauer AU - Aanchal Kapoor AU - Mary Rath AU - Suma A. Thomas TI - What is the role of supplementation with ascorbic acid, zinc, vitamin D, or <em>N</em>-acetylcysteine for prevention or treatment of COVID-19? AID - 10.3949/ccjm.87a.ccc046 DP - 2020 Jun 08 TA - Cleveland Clinic Journal of Medicine 4099 - http://www.ccjm.org/content/early/2020/06/08/ccjm.87a.ccc046.short 4100 - http://www.ccjm.org/content/early/2020/06/08/ccjm.87a.ccc046.full AB - Several agents intended to supplement dietary intake or endogenous molecules may have a theoretical role in preventing or treating COVID-19. Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents.