RT Journal Article SR Electronic T1 Irritable bowel syndrome with diarrhea: Treatment is a work in progress JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 501 OP 511 DO 10.3949/ccjm.87a.19011 VO 87 IS 8 A1 Michael Kurin A1 Gregory Cooper YR 2020 UL http://www.ccjm.org/content/87/8/501.abstract AB Irritable bowel syndrome (IBS) is a heterogeneous functional disease with a high prevalence and significant impact on quality of life. Traditionally understood as a pure disorder of brain-gut interaction, it is increasingly clear that IBS encompasses diverse pathologies, some of which involve objective alterations of intestinal structure, function, and the microbiome. IBS is subclassified as diarrhea, constipation, or mixed type based on the most prominent stool form. We review the diagnosis and management of the diarrheal type through a pathophysiologic lens, with attention to recent developments that can inform a mechanistically based targeted approach to treatment.