TY - JOUR T1 - Cytokine storm release syndrome and the prospects for immunotherapy with COVID-19, part 4: The role of JAK inhibition JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med DO - 10.3949/ccjm.87a.ccc060 AU - Leonard H. Calabrese AU - Tiphaine Lenfant AU - Cassandra Calabrese Y1 - 2020/08/26 UR - http://www.ccjm.org/content/early/2020/08/28/ccjm.87a.ccc060.abstract N2 - This review focuses an alternative strategy utilizing small molecules to inhibit a key signal-transduction pathway, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. The JAK-STAT pathway mediates biologic activity for a large number of inflammatory cytokines and mediators. ER -