RT Journal Article SR Electronic T1 Practical aspects of targeting IL-6 in COVID-19 disease JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic DO 10.3949/ccjm.87a.ccc018 A1 Calabrese, Cassandra A1 Rajendram, Prabalini A1 Sacha, Gretchen L. A1 Calabrese, Leonard YR 2020 UL http://www.ccjm.org/content/early/2020/10/07/ccjm.87a.ccc018.abstract AB Interleukin 6 (IL-6) took center stage as a therapeutic target, given its role in the cytokine storm phase of COVID-19. While IL-6 inhibitors have been widely used to treat a variety of immune-mediated disease states, they have not been used often in the intensive care setting, and new data question their efficacy. This brief review provides practical information on their administration and safety.