RT Journal Article
SR Electronic
T1 The beneficial and pathogenic roles of complement in COVID-19
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
DO 10.3949/ccjm.87a.ccc065
A1 Alfred H.J. Kim
A1 Xiaobo Wu
A1 John P. Atkinson
YR 2020
UL http://www.ccjm.org/content/early/2020/10/27/ccjm.87a.ccc065.abstract
AB We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19.