PT - JOURNAL ARTICLE AU - Yumiko Tsushima AU - M. Cecilia Lansang AU - Vinni Makin TI - The role of SGLT-2 inhibitors in managing type 2 diabetes AID - 10.3949/ccjm.88a.20088 DP - 2021 Jan 01 TA - Cleveland Clinic Journal of Medicine PG - 47--58 VI - 88 IP - 1 4099 - http://www.ccjm.org/content/88/1/47.short 4100 - http://www.ccjm.org/content/88/1/47.full SO - Cleve Clin J Med2021 Jan 01; 88 AB - Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are an exceptionally versatile class of medication, and their glycemic and nonglycemic benefits could help millions of patients with type 2 diabetes. Of note, they have been shown to improve cardiac and renal outcomes, much-needed benefits in patients with type 2 diabetes, who are at a higher risk for developing cardiac and renal dysfunction than those who do not have diabetes. The indications for SGLT-2 inhibitors may continue to expand as ongoing clinical trials provide more insight into these drugs.